Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
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DOI：
10.1007/s13770-022-00503-y
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发表时间：
2023-01
影响因子：
3.6
通讯作者：
Yuntong Sun;Fengtian Sun;Wenrong Xu;Hui Qian
中科院分区：
文献类型：
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作者：
Yuntong Sun;Fengtian Sun;Wenrong Xu;Hui Qian
基于细胞外囊泡（EV）的无细胞策略在组织再生中显示出治疗潜力。由于它们在细胞间通讯中的重要作用以及它们保护货物免受降解的天然能力，EV也成为各种生物活性分子和药物的新型递送载体。越来越多的研究表明，可以对EV进行修饰，以提高其治疗许多疾病的疗效和特异性。工程电动汽车有望成为精确治疗领域的下一代靶向输送平台。本文从生物起源、内含物、表面特征和生物学功能等方面综述了EV的独特性质，并对工程EV构建策略的最新进展进行了总结。此外，我们还讨论了工程EV在癌症和受损组织靶向治疗中的潜在应用，并评估了将其转化为临床实践的机会和挑战。
Extracellular vesicles (EVs)-based cell-free strategy has shown therapeutic potential in tissue regeneration. Due to their important roles in intercellular communications and their natural ability to shield cargos from degradation, EVs are also emerged as novel delivery vehicles for various bioactive molecules and drugs. Accumulating studies have revealed that EVs can be modified to enhance their efficacy and specificity for the treatment of many diseases. Engineered EVs are poised as the next generation of targeted delivery platform in the field of precision therapy. In this review, the unique properties of EVs are overviewed in terms of their biogenesis, contents, surface features and biological functions, and the recent advances in the strategies of engineered EVs construction are summarized. Additionally, we also discuss the potential applications of engineered EVs in targeted therapy of cancer and damaged tissues, and evaluate the opportunities and challenges for translating them into clinical practice.