Cytokines and costimulatory molecules in the immune response to murine gammaherpesvirus-68.
Cytokines and costimulatory molecules in the immune response to murine gammaherpesvirus-68.
复制标题
鼠伽马疱疹病毒 68 免疫反应中的细胞因子和共刺激分子。
DOI：
10.1089/088282404322875412
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发表时间：
2004
期刊：
影响因子：
2.2
通讯作者：
Giannoni,Francesca
中科院分区：
文献类型：
--
作者：
Sarawar,SallyR;Lee,BongJoo;Giannoni,Francesca
Murine gammaherpesvirus 68 (MHV-68) infection of mice provides a useful small animal model for studying gammaherpesvirus pathogenesis and immunity. Recent work has elucidated the cytokine and chemokine profiles during MHV-68 infection and has identified some of the costimulatory interactions that are important for an effective immune response to this virus. Several themes emerge from this work. There is a differential requirement for certain cytokines and costimulatory molecules in the acute and long-term control of MHV-68, and for control of the virus in different anatomical sites. CD4 T cell help is not required for short-term control of MHV-68 in the lung by cytotoxic CD8 T cells, but is essential for effective long-term control. Stimulation via CD40 is an important component of this CD4 T cell help, and interestingly, some of its effects appear to be independent of CD28. MHV-68 infection also increases the expression of several chemokines, which could potentially play important roles in leukocyte trafficking to sites of infection. However, to counter this response, MHV-68 has evolved strategies that enable it to evade or subvert the host chemokine system. Studying the role of cytokines and costimulatory molecules in immunity to MHV-68 may provide useful insights for the development of agents to control gammaherpesviruses that cause human disease.
