Determination of teicoplanin trough concentration target and appropriate total dose during the first 3 days: a retrospective study in patients with MRSA infections
Determination of teicoplanin trough concentration target and appropriate total dose during the first 3 days: a retrospective study in patients with MRSA infections
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DOI：
10.1007/s10156-010-0038-8
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Yamada, Katsushi
中科院分区：
文献类型：
--
作者：
Matsumoto, Kazuaki;Kanazawa, Naoko;Yamada, Katsushi
建议采用初始负荷程序，使替考拉宁迅速达到治疗耐甲氧西林金黄色葡萄球菌（MRSA）的有效血清浓度。本研究旨在回顾性评价替考拉宁的药代动力学和药效学，以确定前3天替考拉宁谷浓度的治疗目标和适当的给药方法。MRSA根除患者的平均谷浓度为13.2 mg/L。此外，logistic回归分析显示替考拉宁谷浓度为13 mg/L，实现MRSA根除的概率为89.0%。在千分之一货币符号24、24-36和千分之一日元36 mg/kg（前3天的总剂量）组中，达到千分之一日元13 mg/L的比率分别为9.1%、48.4%和87.5%。这些结果表明，在最初3天内给予36 mg/kg的剂量，对于MRSA感染的初始治疗而言，可迅速达到13 mg/L的谷浓度目标。
An initial loading procedure has been recommended to enable teicoplanin to promptly reach an effective serum concentration for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to retrospectively evaluate the pharmacokinetics and pharmacodynamics of teicoplanin to determine the therapeutic target for the teicoplanin trough concentration and an appropriate dosing method during the first 3 days. The mean trough concentrations were 13.2 mg/L for patients with eradication of MRSA. Moreover, logistic regression analysis showed that the teicoplanin trough concentration was 13 mg/L to achieve MRSA eradication with a probability of 89.0%. The rates of achieving a parts per thousand yen13 mg/L in a parts per thousand currency sign24, 24-36 and a parts per thousand yen36 mg/kg (total dose during the first 3 days) groups were 9.1, 48.4 and 87.5%, respectively. These results suggest that the administration of a parts per thousand yen36 mg/kg during the first 3 days is appropriate to promptly obtain a trough concentration target of a parts per thousand yen13 mg/L for the initial treatment of MRSA infections.