Noncanonical Wnt Signaling in Tumor Progression and Metastasis
Noncanonical Wnt Signaling in Tumor Progression and Metastasis
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DOI：
10.1089/zeb.2008.0571
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发表时间：
2009-03-01
期刊：
影响因子：
2
通讯作者：
Jessen, Jason R.
中科院分区：
文献类型：
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作者：
Jessen, Jason R.
近 15 年来，非经典（不依赖 β-连环蛋白）Wnt 信号通路在胚胎发育中发挥关键作用的概念在科学文献中稳步增长。在了解这些途径如何调节原肠胚细胞运动和纤毛形成等多种形态发生过程方面，已经取得了重大进展。然而，最近的数据表明，非经典 Wnt/Ca2+ 和 Wnt/平面细胞极性信号传导的成分可直接促进多种人类癌症的侵袭性和恶性进展。在这里，我使用发育模型系统的数据回顾了这一新兴的癌症研究领域，以提供解决未来问题的框架。
For almost 15 years, the concept that noncanonical (beta-catenin-independent) Wnt signaling pathways play key roles in embryonic development has grown steadily in the scientific literature. Significant progress has been made toward understanding how these pathways regulate morphogenetic processes as diverse as gastrulation cell movements and the formation of cilia. More recently, however, data have implicated components of noncanonical Wnt/Ca2+ and Wnt/planar cell polarity signaling in directly promoting the invasiveness and malignant progression of diverse forms of human cancer. Here I review this emerging field of cancer research using data from developmental model systems to provide a framework for addressing future questions.