Epigenetic mechanisms in heart development and disease.
Epigenetic mechanisms in heart development and disease.
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DOI：
10.1016/j.drudis.2014.12.018
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发表时间：
2015-07
影响因子：
7.4
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Martinez SR;Gay MS;Zhang L
宫内发育不佳与成年后易患心血管疾病有关，这一概念被称为“健康和疾病的发育起源”。尽管这种发育程序背后的确切机制尚不清楚，但越来越多的证据支持表观遗传调控的参与。表观遗传机制，如DNA甲基化、组蛋白修饰和微rna，在不改变DNA序列的情况下，赋予了基因调控的额外水平。这些修饰是相对稳定的信号，为了解健康和疾病的发育起源机制提供了可能。本文将讨论表观遗传机制在心脏发育中的作用以及异常表观遗传调控对心血管疾病的影响。此外，我们将讨论最近针对表观遗传机制作为心血管疾病潜在治疗方法的进展。
Suboptimal intrauterine development has been linked to predisposition to cardiovascular disease in adulthood, a concept termed ‘developmental origins of health and disease’. Although the exact mechanisms underlying this developmental programming are unknown, a growing body of evidence supports the involvement of epigenetic regulation. Epigenetic mechanisms such as DNA methylation, histone modifications and micro-RNA confer added levels of gene regulation without altering DNA sequences. These modifications are relatively stable signals, offering possible insight into the mechanisms underlying developmental origins of health and disease. This review will discuss the role of epigenetic mechanisms in heart development as well as aberrant epigenetic regulation contributing to cardiovascular disease. Additionally, we will address recent advances targeting epigenetic mechanisms as potential therapeutic approaches to cardiovascular disease.