Calcium-sensitive inactivation in the gating of single calcium channels.
Calcium-sensitive inactivation in the gating of single calcium channels.
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单个钙通道门控中的钙敏感失活。
DOI：
10.1126/science.2176745
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Imredy,JP
中科院分区：
文献类型：
--
作者：
Yue,DT;Backx,PH;Imredy,JP
电压激活的钙通道根据由跨膜电压和神经递质调节的分子转换速率打开和关闭或门控。在此，在心脏细胞中单个L型钙通道的电生理记录中发现了钙控制门控的证据。条件开放概率分析表明，钙离子进入在一个单一的通道开放过程中产生的门控转换率的变化，在数百毫秒的过程中演变。通过有利的渗透离子的进入的钙通道门控的这种改变为单离子通道的短期调节提供了机制。
Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.