Normal Dynamic MRI Enhancement Patterns of the Upper Abdominal Organs: Gadoxetic Acid Compared With Gadobutrol
Normal Dynamic MRI Enhancement Patterns of the Upper Abdominal Organs: Gadoxetic Acid Compared With Gadobutrol
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DOI：
10.2214/ajr.09.2412
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发表时间：
2009-11-01
影响因子：
5
通讯作者：
Puls, Ralf
中科院分区：
文献类型：
--
作者：
Kuehn, Jens-Peter;Hegenscheid, Katrin;Puls, Ralf
目标。本研究的目的是探讨在上腹部器官的动态MRI上，加多etic酸（一种肝胆造影剂）的增强效果是否与细胞外造影剂的效果相当。研究对象和方法。对50例患者行胰、脾、肾、肝、腹主动脉动态增强MRI检查；对照组50例患者行动态加多布诺增强MRI；然后对图像进行比较。在静脉注射gadoxetic酸（0.25 mmol/mL）或gadobutrol （1.0 mmol/mL）前、后20秒（动脉期）、55秒（门静脉期）和90秒（肝静脉期）进行t1加权容积内插式屏气检查梯度回声序列（TR/TE, 3.35/1.35；翻转角度，12度）动态成像。计算各器官和时间的信噪比和增强指数。两组mri图像均符合诊断质量。在早期动态期，胰腺的平均增强指数明显低于加多酚组(门静脉期，0.66,1.39,p
OBJECTIVE. The purpose of this study was to investigate whether, at dynamic MRI of the upper abdominal organs, contrast enhancement with gadoxetic acid, a hepatobiliary contrast agent, is comparable with that achieved with an extracellular contrast agent.SUBJECTS AND METHODS. Dynamic gadoxetic acid-enhanced MRI of the pancreas, spleen, kidney, liver, and abdominal aorta was performed on 50 patients; dynamic gadobutrol-enhanced MRI was performed on a control group of 50 patients; and the images were compared. Dynamic imaging with a T1-weighted volumetric interpolated breath-hold examination gradient-echo sequence (TR/TE, 3.35/1.35; flip angle, 12 degrees) was performed before and 20 (arterial phase), 55 (portal venous phase), and 90 (hepatic venous phase) seconds after bolus injection of gadoxetic acid (0.25 mmol/mL) or gadobutrol (1.0 mmol/mL). Signal-to-noise ratios and enhancement indexes were calculated for each organ and time.RESULTS. All MR images in both groups were of diagnostic quality. During the early dynamic phases, significantly lower mean enhancement indexes were found in the gadoxetic acid group than in the gadobutrol group in the pancreas (portal venous phase, 0.66, 1.39, p