Acetylsalicylic Acid Treatment Improves Differentiation and Immunomodulation of SHED
Acetylsalicylic Acid Treatment Improves Differentiation and Immunomodulation of SHED
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DOI：
10.1177/0022034514557672
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发表时间：
2015-01-01
影响因子：
7.6
通讯作者：
Shi, S.
中科院分区：
文献类型：
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作者：
Liu, Y.;Chen, C.;Shi, S.
来自脱落乳牙 (SHED) 的干细胞具有多能分化和免疫调节特性。它们已用于口面部骨再生和自身免疫性疾病的治疗。在这项研究中，我们表明乙酰水杨酸（ASA）治疗能够显着改善 SHED 介导的成骨分化和免疫调节。从机制上讲，ASA治疗上调端粒酶逆转录酶（TERT）/Wnt/β-连环蛋白级联，从而改善SHED介导的骨再生，并且还上调TERT/FASL信号传导，从而改善SHED介导的T细胞凋亡并改善右旋糖酐硫酸钠诱导的结肠炎小鼠的疾病表型。这些数据表明 ASA 治疗是改善基于 SHED 的细胞疗法的实用方法。
Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration and autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic differentiation and immunomodulation. Mechanistically, ASA treatment upregulates the telomerase reverse transcriptase (TERT)/Wnt/beta-catenin cascade, leading to improvement of SHED-mediated bone regeneration, and also upregulates TERT/FASL signaling, leading to improvement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfate-induced colitis mice. These data indicate that ASA treatment is a practical approach to improving SHED-based cell therapy.