Levetiracetam-associated aggravation of myoclonic seizure in children
Levetiracetam-associated aggravation of myoclonic seizure in children
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DOI：
10.1016/j.seizure.2012.08.008
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发表时间：
2012-12
期刊：
影响因子：
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通讯作者：
Yong-hong Liu;Xiao-Li Wang;Yanchun Deng;Gang Zhao
中科院分区：
文献类型：
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作者：
Yong-hong Liu;Xiao-Li Wang;Yanchun Deng;Gang Zhao
一些抗癫痫药物（AEDs）已报告加重全身性癫痫发作。我们已经看到三个孩子的肌阵挛发作增加开始治疗左乙拉西坦。在所有癫痫发作中，病情加重与药物的引入存在时间相关性。所有患者在停用左乙拉西坦并改用替代抗癫痫药物后均无癫痫发作，并持续至少6个月。这表明，一些肌阵挛性癫痫发作的儿童在开始左乙拉西坦治疗时可能会加重病情，但这需要进一步研究。
Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this persisted for at least 6 months. This suggests that some children with myoclonic seizures may have an aggravation on starting treatment with levetiracetam but this requires further studies.