Avascular necrosis of bone in systemic lupus erythematosus: possible role of haemostatic abnormalities.
Avascular necrosis of bone in systemic lupus erythematosus: possible role of haemostatic abnormalities.
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系统性红斑狼疮骨缺血性坏死：止血异常的可能作用。
DOI：
10.1136/ard.48.8.672
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发表时间：
1989
影响因子：
27.4
通讯作者：
Yoshiyuki Niho
中科院分区：
文献类型：
--
作者：
Kohei Nagasawa;Yoshitomo Ishii;T. Mayumi;Y. Tada;Akira Ueda;Y. Yamauchi;T. Kusaba;Yoshiyuki Niho
对111例系统性红斑狼疮(SLE)患者(ANB组24例，非ANB组87例)的发病机制进行了研究，分析了患者的年龄、糖皮质激素治疗、SLE相关的临床和实验室特征以及止血谱。诊断为SLE的ANB患者和非ANB患者的平均年龄分别为24.1岁和31.2岁。ANB组强的松龙平均每日最大剂量为50.8 mg，显著高于非ANB组的41.8 mg。未发现系统性红斑狼疮的疾病特征，如雷诺现象、高脂血症、肾病综合征、高血压和疾病活动性与ANB无关。有ANB的患者使用狼疮抗凝剂的百分比以及活化的部分凝血活酶时间比没有ANB的患者更多。系统性红斑狼疮ANB的发病可能涉及多种因素，提示止血功能异常在ANB的发生发展中起一定作用，糖皮质激素和年龄对ANB的影响较大。
The pathogenesis of avascular necrosis of bone (ANB) was investigated in 111 patients with systemic lupus erythematosus (SLE) (24 with ANB, 87 without ANB); patients' ages, corticosteroid treatment, clinical and laboratory features associated with SLE, and haemostatic profiles were all taken into account. The mean ages of patients with and without ANB at the time of diagnosis of SLE was 24.1 and 31.2 years respectively. The mean maximal daily dose of prednisolone in the group with ANB was 50.8 mg, which was significantly higher than the dose (41.8 mg) in the group without ANB. Disease features of SLE, such as Raynaud's phenomenon, hyperlipidaemia, nephrotic syndrome, hypertension, and disease activity, were not found to be related to ANB. The percentage of patients who had lupus anticoagulant as well as a shorter activated partial thromboplastin time was greater in those with ANB than in those without. Multiple factors may be involved in the pathogenesis of ANB in SLE, and it is suggested that haemostatic abnormalities, which could be influenced by corticosteroids and young ages, play some part in the development of ANB.
年轻患者系统性红斑狼疮引起的缺血性心脏病：六例报告。
DOI：
10.1016/0002-9149(82)90528-8
发表时间：
1982
期刊：
The American journal of cardiology
影响因子：
--
作者：
Homcy,CJ;Liberthson,RR;Fallon,JT;Gross,S;Miller,LM
通讯作者：
Miller,LM