The role of miR-183 cluster in immunity
The role of miR-183 cluster in immunity
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DOI：
10.1016/j.canlet.2018.11.035
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发表时间：
2019-01-01
期刊：
影响因子：
9.7
通讯作者：
Dong, Chen
中科院分区：
文献类型：
--
作者：
Ichiyama, Kenji;Dong, Chen
microRNA（miRNAs）是一个广泛保守的转录后过程中调控基因表达的重要因子。miRNAs在免疫中起着关键作用，包括控制各种免疫细胞的分化以及它们的免疫功能。miR-183簇由miR-183、-96和-182组成，是具有序列同源性的miRNA家族。这些miRNA通常在发育过程中一起转录为多顺反子miRNA簇，并且是感觉器官成熟所需的。与这些miRNA在正常发育中的定义的感觉特异性作用相比，它们经常在几种非感觉疾病中过度表达，包括自身免疫性疾病和癌症。由于miR-183簇的单个miRNAs在功能相关的通路中具有共同和独特的靶点，它们可以对生物过程显示协同或相反的作用，这意味着这种mift簇介导的基因调控的复杂性。因此，更好地理解miR-183簇表达及其下游网络的分子调控对于治疗应用是重要的。本文就miR-183簇的特征及其在免疫系统中的作用进行综述。本文总结的新知识将有助于读者了解miR-183簇在该领域的多功能作用。
MicroRNAs (miRNAs) are essential factors of an extensively conserved post-transcriptional process to regulate gene expression. MiRNAs play a pivotal role in immunity, including controlling the differentiation of various immune cells as well as their immunological functions. The miR-183 cluster, which is comprised of miR-183,-96 and -182, is a miRNA family with sequence homology. These miRNAs are usually transcribed together as a polycistronic miRNA cluster during development and are required for maturation of sensory organs. In comparison to defined sensory-specific role of these miRNAs in normal development, they are frequently over expressed in several non-sensory diseases, including autoimmune diseases and cancers. Because individual miRNAs of miR-183 cluster have both common and unique targets within functionally interrelated pathways, they can show cooperative or opposing effects on biological processes, implying the complexity of this mift cluster-mediated gene regulation. Therefore, a better understanding of the molecular regulation of miR-183 cluster expression and its downstream networks is important for the therapeutic applications. In this review, we will discuss the characteristics of miR-183 cluster and a wide variety of evidence on its function in immune system. Newer knowledge summarized here will help readers understand the versatile role of miR-183 cluster in this field.