SLEEP APNEA, HYPOPNEA AND OXYGEN DESATURATION IN NORMAL SUBJECTS - STRONG MALE PREDOMINANCE
SLEEP APNEA, HYPOPNEA AND OXYGEN DESATURATION IN NORMAL SUBJECTS - STRONG MALE PREDOMINANCE
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DOI：
10.1056/nejm197903083001001
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
HUNT, LA
中科院分区：
文献类型：
--
作者：
BLOCK, AJ;BOYSEN, PG;HUNT, LA
无症状男性（30例）和19例无症状女性在1夜睡眠中进行监测，以确定正常受试者呼吸异常和O2去饱和的发生率。男性（20例）占夜间氧饱和度下降或呼吸异常的264次发作。女性从未经历过氧饱和度下降;只有3例共发生9次呼吸暂停。这些性别差异有高度显著性（P < 0.003）。在男性中，年龄增加和肥胖与夜间氧饱和度下降和呼吸异常的发生率呈正相关。体重超过90 kg的无症状男性（4）的饱和度降至非常低的水平（68-72%）。慢性阻塞性肺疾病或周期性呼吸嗜睡综合征患者睡眠期间的异常呼吸和O2去饱和可能代表吸烟或肥胖与男性打鼾和O2去饱和正常倾向的叠加。
Asymptomatic men (30) and 19 asymptomatic women were monitored during 1 night''s sleep to determine the incidence of breathing abnormalities and O2 desaturation in normal subjects. Men (20) accounted for 264 episodes of nocturnal O2 desaturation or abnormal breathing. Women never experienced O2 desaturation; only 3 had a total of 9 episodes of apnea. These sex differences were highly significant (P < 0.003). In men, increasing age and obesity correlated positively with the incidence of nocturnal O2 desaturation and abnormal breathing. Asymptomatic men (4) weighing more than 90 kg dropped their saturation to very low levels (68-72%). Abnormal breathing and O2 desaturation during sleep in subjects with chronic obstructive lung disease or the syndrome of hypersomnolence with periodic breathing may represent the superimposition of smoking or obesity on a normal tendency to snoring and O2 desaturation in men.