Correlation between gastrointestinal fungi and varying degrees of chronic hepatitis B virus infection
Correlation between gastrointestinal fungi and varying degrees of chronic hepatitis B virus infection
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DOI：
10.1016/j.diagmicrobio.2010.04.005
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发表时间：
2011-08-01
影响因子：
2.9
通讯作者：
Li, Lanjuan
中科院分区：
文献类型：
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作者：
Chen, Yu;Chen, Zhenjing;Li, Lanjuan
本研究旨在比较不同程度慢性B型肝炎病毒（HBV）感染患者肠道真菌菌群的多样性。对38例B型肝炎肝硬化患者、35例慢性B型肝炎患者、33例HBV携带者和55例健康志愿者进行了非培养和依赖培养的方法。一个整体的真菌生物多样性的37个不同的操作分类单位被发现在克隆库中，只有念珠菌属。和酿酒酵母通过培养依赖性分析获得。B型肝炎肝硬化患者的真菌种类丰富度高于慢性B型肝炎患者，后者高于HBV携带者和健康志愿者。HBV携带者和健康志愿者肠道真菌多样性差异不大。结果表明，肠道真菌的多样性与不同程度的慢性HBV感染患者的疾病进展呈正相关。(C)2011 Elsevier Inc. All rights reserved.
This study aims to compare the diversity of intestinal fungal microbiota in patients with different degrees of chronic hepatitis B virus (HBV) infection. Culture-independent and culture-dependent methods were performed on 38 patients with hepatitis B cirrhosis, 35 patients with chronic hepatitis B, 33 HBV carriers, and 55 healthy volunteers. An overall fungal biodiversity of 37 different operational taxonomic units was found in the clone libraries; only Candida spp. and Saccharomyces cerevisiae were obtained by the culture-dependent analysis. There was a higher richness of fungal species in patients with hepatitis B cirrhosis than in patients with chronic hepatitis B, and the latter was higher than that in HBV carriers and healthy volunteers. There was little difference in enteric fungal diversity between HBV carriers and healthy volunteers. The results indicate that the diversity of enteric fungi was positively correlated with the disease progression of patients with different degrees of chronic HBV infection. (C) 2011 Elsevier Inc. All rights reserved.