Postural performance in decerebrated rabbit
Postural performance in decerebrated rabbit
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DOI：
10.1016/j.bbr.2008.02.011
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发表时间：
2008-06-26
影响因子：
2.7
通讯作者：
Deliagina, T. G.
中科院分区：
文献类型：
--
作者：
Musienko, P. E.;Zelenin, P. V.;Deliagina, T. G.
众所周知，在前乳头水平去大脑的动物能够站立和行走而不会失去平衡，而后乳头水平的动物则不表现出这种行为。本研究的主要目标是，首先，表征乳头前兔子的姿势表现，其次，通过脑干刺激激活乳头后兔子的姿势系统。为了评估去脑兔的姿势能力，记录去脑前后对支撑平台侧向倾斜和侧向推动的运动和肌电图反应。此外，还对翻正行为（即从躺着的位置站起来）进行了视频记录。我们发现，在乳头未成熟的兔子中，对侧向倾斜和推力的反应与在完整兔子中观察到的相似，但反应的幅度有所降低。在翻正过程中，前乳头兔比完整兔恢复正常位置的速度慢。为了激活后乳头兔的姿势系统，我们对两个脑干结构进行电刺激，即中脑运动区（MLR）和腹侧被盖区（VTF）。 NILR 刺激（在引发运动之前）和 VTF 刺激导致后肢伸肌张力增加，并增强其对侧向倾斜和推力的反应。这些结果表明，去大脑动物中存在维持站立期间身体姿势和平衡的基本机制。它们在乳头前的兔子中很活跃，但在乳头后的兔子中需要被激活。 (c) 2008 Elsevier B.V. 保留所有权利。
It is known that animals decerebrated at the premammillary level are capable of standing and walking without losing balance, in contrast to postmammillary ones which do not exhibit such behavior. The main goals of the present study were, first, to characterize the postural performance in premammillary rabbits, and, second, to activate the postural system in postmammillary ones by brainstem stimulation. For evaluation of postural capacity of decerebrated rabbits, motor and EMG responses to lateral tilts of the supporting platform and to lateral pushes were recorded before and after decerebration. In addition, the righting behavior (i.e., standing up from the lying position) was video recorded.We found that, in premammillary rabbits, responses to lateral tilts and pushes were similar to those observed in intact ones, but the magnitude of responses was reduced. During righting, premammillary rabbits assumed the normal position slower than intact ones.To activate the postural system in postmammillary rabbits, we stimulated electrically two brainstem structures, the mesencephalic locomotor region (MLR) and the ventral tegmental field (VTF). The NILR stimulation (prior to elicitation of locomotion) and the VTF stimulation caused an increase of the tone of hindlimb extensors, and enhanced their responses to lateral tilts and to pushes.These results indicate that the basic mechanisms for maintenance of body posture and equilibrium during standing are present in decerebrated animals. They are active in the premammillary rabbits but need to be activated in the postmammillary ones. (c) 2008 Elsevier B.V. All rights reserved.