Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia
Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia
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DOI：
10.1016/s0920-9964(96)00098-9
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发表时间：
1997-05-03
影响因子：
4.5
通讯作者：
Green, AI
中科院分区：
文献类型：
--
作者：
Berman, I;Viegner, B;Green, AI
方法采用精神分裂症阳性和阴性症状量表(PANSS)和一系列认知测验对30例缓解期精神分裂症患者进行评定。PANSS评估是由一组对认知测试结果视而不见的评分员进行的，而认知测试是由另一组对PANSS分数视而不见的评分员进行的。结果：我们发现，虽然阳性症状和阴性症状呈现出相互直接相关的趋势，但它们与明显的认知障碍相关。负分越高的患者在威斯康星卡片分类测试中有更多的持久力反应和持久性错误，完成的类别也更少；他们在试探和语言流利性测试中也经历了更多的困难。另一方面，阳性症状与数字跨度，特别是向前数字跨度的糟糕表现有关。结论：我们的发现与以前的报告一致，即阴性症状可能与反映额叶功能的认知测试表现不佳有关。另一方面，积极的症状似乎与注意力不集中有关，特别是听觉类型，因此可能与更广泛的神经网络中潜在的注意力障碍有关。我们的发现支持这样的假设，即积极和消极的症状可能与不同的神经心理缺陷有关，从而与不同的神经基础有关，并指出在研究精神分裂症时需要同时处理积极和消极的方面。
This study assessed the relationships between positive and negative clinical symptoms and specific neuropsychological deficits in a group of stable schizophrenic patients, Method Thirty patients were assessed using the Positive and Negative Syndrome Scale (PANSS) for schizophrenia and a battery of cognitive tests. The PANSS assessments were done by a group of raters blind to the results of cognitive tests, while the cognitive tests were conducted by a different group of raters who remained blind to the PANSS scores. Results: We found that, although positive and negative symptoms showed a trend toward direct correlation with each other, they correlated with distinct cognitive deficits. Patients with higher negative scores had more perseverative responses, perseverative errors, and completed fewer categories on the Wisconsin Card Sorting Test; they also experienced more difficulties on trail making and verbal fluency tests. On the other hand, positive symptoms were associated with poor performance on the Digit Span, particularly the Digit Span Forward. Conclusions: Our findings are in agreement with previous reports that negative symptoms may be associated with poor performance on cognitive tests reflecting particularly frontal function. Positive symptoms, on the other hand, seem to be associated with poor attention, specifically of auditory type, and thus, possibly with dysfunction within the more widespread neural networks underlying attention. Our findings support the hypothesis that positive and negative symptoms may be associated with distinct neuropsychological deficits and thus with distinct neurological substrates and point to the need to address both positive and negative dimensions when studying schizophrenia.