Hyperhomocysteinemia is a risk factor for postoperative ischemia in adult patients with moyamoya disease
Hyperhomocysteinemia is a risk factor for postoperative ischemia in adult patients with moyamoya disease
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高同型半胱氨酸血症是成年烟雾病患者术后缺血的危险因素
DOI：
10.1007/s10143-021-01482-9
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发表时间：
2021-01-27
影响因子：
2.8
通讯作者：
Zhao, Jizong
中科院分区：
文献类型：
--
作者：
Li, Junsheng;Ge, Peicong;Zhao, Jizong
越来越多的证据表明高同型半胱氨酸血症（HHcy）是脑梗塞的危险因素。但HHcy对术后脑缺血的影响尚不清楚。我们的目的是探讨 HHcy 与成人烟雾病 (MMD) 患者术后缺血的关系。 2019年7月1日至12月31日前瞻性招募138名成年MMD患者。排除14名接受保守治疗的患者后，全部124名接受手术治疗的患者入组。分别根据术后缺血和 HHcy 表现对患者进行分组。通过统计分析比较临床数据和实验室检查。通过单变量和多变量逻辑回归分析评估潜在的危险因素。与正常人相比，术后缺血患者血清同型半胱氨酸（Hcy）水平（P=0.039）和HHcy比值（P=0.035）较高。此外，HHcy 在男性中比女性更常见（P = 0.007）。 Logistic分析结果显示，HHcy（OR 5.234，95% CI 1.127~24.315；P=0.035）是独立危险因素。 HHcy 与 MMD 患者术后缺血显着相关。我们的研究发现 HHcy 与术后缺血的风险相关。 HHcy可作为成年MMD患者术后缺血的指标和潜在的治疗靶点。网址：http://www.chictr.org。唯一标识符：ChiCTR2000031412。
Growing evidence has suggested that hyperhomocysteinemia (HHcy) is a risk factor for cerebral infarction. However, the effect of HHcy on postoperative cerebral ischemia is still unclear. We aim to investigate the relationship between HHcy and postoperative ischemia of adult patients with moyamoya disease (MMD). A total of 138 adult patients with MMD were prospectively recruited from July 1 to December 31, 2019. After excluding 14 patients accepting conservative therapy, all 124 patients who underwent surgical treatment were enrolled. Patients were grouped according to postoperative ischemia and HHcy presentation, respectively. Clinical data and laboratory examinations were compared by statistical analyses. Potential risk factors were evaluated by univariate and multivariate logistic regression analysis. Comparing to the normal, patients with postoperative ischemia were higher in serum homocysteine (Hcy) level (P= 0.039) and HHcy ratio (P= 0.035). Furthermore, HHcy was more common in males (P= 0.007) than females. Logistic analysis results showed that HHcy (OR 5.234, 95% CI 1.127–24.315;P= 0.035) was an independent risk factor. HHcy was significantly associated with postoperative ischemia in MMD patients. Our study found that HHcy was correlated to the risk of postoperative ischemia. HHcy can be used as an indicator and a potential therapeutic target for postoperative ischemia in adult patients with MMD. URL: http://www.chictr.org . Unique identifier: ChiCTR2000031412.