Noradrenergic innervation of the hypothalamus participates in adrenocortical responses to interleukin-1.
Noradrenergic innervation of the hypothalamus participates in adrenocortical responses to interleukin-1.
复制标题
下丘脑的去甲肾上腺素能神经支配参与肾上腺皮质对白介素-1 的反应。
DOI：
10.1159/000126215
复制
发表时间：
1992
影响因子：
4.1
通讯作者：
Dunn,AJ
中科院分区：
文献类型：
--
作者：
Chuluyan,HE;Saphier,D;Rohn,WM;Dunn,AJ
应激和免疫激活与血浆皮质酮（CS）浓度的增加有关。为了确定是否在下丘脑室旁核（PVN）的神经元的儿茶酚胺能神经支配参与这些反应，选择性病变使用6-羟基多巴胺（6-OHDA）。PVN内注射6-OHDA可使NE含量减少85%，并使腹腔注射重组人白细胞介素-1 α（IL-1）后血浆CS浓度的升高降低80-82%，但不影响肾上腺皮质对20分钟束缚的反应。将6-OHDA注射到腹侧去甲肾上腺素能升束中，使PVN NE含量减少77%。该病变使CS对人IL-1α的反应降低了82- 86%，但在束缚20 min时没有改变，尽管束缚3 min后CS反应无显著性降低。这些结果表明，去甲肾上腺素能神经支配的PVN介导的激活下丘脑-垂体-肾上腺（HPA）轴的腹腔注射IL-1。可能有去甲肾上腺素的贡献HPA反应的约束，但其他神经通路可能也参与了这一反应。
Stress and immune activation are associated with increases in plasma concentrations of corticosterone (CS). To determine whether the catecholaminergic innervation of neurons in the hypothalamic paraventricular nucleus (PVN) is involved in these responses, selective lesions were made using 6-hydroxydopamine (6-OHDA). Injection of 6-OHDA into the PVN depleted its norepin-phrine (NE) content by 85% and reduced by 80-82% the increase in plasma CS concentrations following intraperitoneal injection of recombinant human interleukin-1α (IL-1), but did not affect the adrenocortical response to 20 min restraint. Injection of 6-OHDA into the ventral noradrenergic ascending bundle depleted PVN NE content by 77%. This lesion reduced the CS response to human IL-1α by 82-86%, but did not alter that to 20 min restraint, although there was a nonsignificant decrease in the CS response following 3 min of restraint. These results suggest that the noradrenergic innervation of the PVN mediates the activation of the hypothalamic-pituitary-adrenal (HPA) axis by intraperitoneally injected IL-1. There may be a noradrenergic contribution to the HPA response to restraint, but other neural pathways probably also participate in this response.