Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation
Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation
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DOI：
10.1021/acs.est.2c00885
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发表时间：
2021-07
影响因子：
11.4
通讯作者：
Hongchen Shen;Zhe Zhou;Haihuan Wang;Mengyang Zhang;Minghao Han;Yun Shen;Danmeng Shuai
中科院分区：
文献类型：
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作者：
Hongchen Shen;Zhe Zhou;Haihuan Wang;Mengyang Zhang;Minghao Han;Yun Shen;Danmeng Shuai
为了应对 SARS-CoV-2 空气传播的挑战，制造了光敏电纺纳米纤维膜来有效捕获和灭活冠状病毒气溶胶。优化的膜具有超细纤维直径（约 200 nm）和小孔径（约 1.5 µm），可捕获 99.2% 的鼠肝炎病毒 A59 (MHV-A59)（SARS-CoV-2 的冠状病毒替代品）的气溶胶。此外，孟加拉玫瑰因其在产生杀病毒单线态氧方面具有优异的反应活性而被用作膜的光敏剂，仅在模拟阅读灯照射15分钟后，该膜就迅速灭活了载有病毒的飞沫中98.9%的MHV-A59。单线态氧破坏了病毒基因组并削弱了病毒与宿主细胞的结合，这在分子水平上阐明了消毒机制。还评估了膜的稳健性，在膜暴露于室内光和阳光几天后，没有观察到过滤 MHV-A59 气溶胶的效率降低。然而，阳光照射会使膜发生光漂白，减少单线态氧的产生，并损害对液滴中 MHV-A59 的消毒性能。相比之下，模拟室内光照后的膜仍保持其优异的消毒性能。总之，光敏电纺纳米纤维膜已被开发用于捕获和杀死环境条件下空气中的环境病原体，并且它们有望作为个人防护设备和室内空气过滤器广泛应用。概要 光敏电纺纳米纤维过滤器具有出色的冠状病毒捕获和杀灭性能，旨在防止 COVID-19 的空气传播。目录
To address the challenge of the airborne transmission of SARS-CoV-2, photosensitized electrospun nanofibrous membranes were fabricated to effectively capture and inactivate coronavirus aerosols. With an ultrafine fiber diameter (∼ 200 nm) and a small pore size (∼ 1.5 µm), the optimized membranes caught 99.2% of the aerosols of the murine hepatitis virus A59 (MHV-A59), a coronavirus surrogate for SARS-CoV-2. In addition, rose bengal was used as the photosensitizer for the membranes because of its excellent reactivity in generating virucidal singlet oxygen, and the membranes rapidly inactivated 98.9% of MHV-A59 in virus-laden droplets only after 15 min irradiation of simulated reading light. Singlet oxygen damaged the virus genome and impaired virus binding to host cells, which elucidated the mechanism of disinfection at a molecular level. Membrane robustness was also evaluated, and no efficiency reduction for filtering MHV-A59 aerosols was observed after the membranes being exposed to both indoor light and sunlight for days. Nevertheless, sunlight exposure photobleached the membranes, reduced singlet oxygen production, and compromised the performance of disinfecting MHV-A59 in droplets. In contrast, the membranes after simulated indoor light exposure maintained their excellent disinfection performance. In summary, photosensitized electrospun nanofibrous membranes have been developed to capture and kill airborne environmental pathogens under ambient conditions, and they hold promise for broad applications as personal protective equipment and indoor air filters. Synopsis Photosensitized electrospun nanofibrous filters with excellent capture-and-kill performance against coronaviruses were designed and implemented to prevent the airborne transmission of COVID-19. Table of Contents