Enterogastrone-like effect of peptide YY is vagally mediated in the dog.
Enterogastrone-like effect of peptide YY is vagally mediated in the dog.
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在狗中，肽 YY 的肠胃素样作用是通过迷走神经介导的。
DOI：
10.1172/jci112300
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Taylor,IL
中科院分区：
文献类型：
--
作者：
Pappas,TN;Debas,HT;Taylor,IL
管腔内脂肪通过尚未确定的机制抑制胃分泌，该机制涉及一种或多种激素肠抑胃素的释放。由于腔内脂肪释放的肽YY（PYY）的量足以抑制膳食刺激的酸分泌，因此这种回结肠肽表现出肠胃激素所需的特征。本研究旨在通过检查PYY对五肽胃泌素、组胺和氨甲酰胆碱刺激的胃酸的影响来确定PYY抑制胃酸分泌的机制。此外，PYY对假喂食和去神经胃袋扩张的酸反应的影响进行了检查。采用的PYY剂量（400 pmol X kg-1 X h-1）重现了用油酸进行肠灌注后观察到的血液水平，并抑制了对胃内进餐的酸分泌反应35 +/-6%。相同剂量的PYY最大抑制组胺和五肽胃泌素刺激的酸分泌分别为28 +/- 7%（P <0.05）和17 +/- 4%（P <0.05）。虽然PYY对氨甲酰胆碱刺激的分泌没有影响，但它显著抑制对假喂食的分泌反应，最大减少分泌90 +/- 4%（P <0.01）。我们推测PYY通过抑制迷走神经纤维释放乙酰胆碱而不是抑制乙酰胆碱对壁细胞的作用。PYY实际上消除了头期酸分泌，同时对外源性促分泌素的反应几乎没有影响，这一证明使PYY在已知的胃分泌激素抑制剂中具有独特的特征。
Intraluminal fat inhibits gastric secretion through as yet undetermined mechanisms which involve release of one or more hormonal enterogastrones. As intraluminal fat releases Peptide YY (PYY) in amounts sufficient to inhibit meal-stimulated acid secretion, this ileo-colonic peptide exhibits the characteristics required of an enterogastrone. The present study seeks to determine the mechanism by which PYY inhibits acid secretion by examining the effects of PYY on gastric acid stimulated by pentagastrin, histamine, and bethanechol. In addition, effects of PYY on the acid response to sham feeding and distention of a denervated gastric pouch were examined. A dose of PYY (400 pmol X kg-1 X h-1) was employed that reproduced blood levels observed after intestinal perfusion with oleic acid and inhibited the acid secretory response to an intragastric meal by 35 +/- 6%. This same dose of PYY maximally inhibited histamine- and pentagastrin-stimulated acid secretion by 28 +/- 7% (P less than 0.05), and 17 +/- 4% (P less than 0.05), respectively. Although PYY had no effect on bethanechol-stimulated secretion it markedly inhibited the secretory response to sham feeding, maximally reducing secretion by 90 +/- 4% (P less than 0.01). We speculate that PYY acts by inhibiting acetylcholine release from vagal nerve fibers rather than by inhibiting acetylcholine's action on the parietal cell. The demonstration that PYY virtually abolishes cephalic phase acid secretion while having little if any effect on the response to exogenous secretogogues gives PYY unique characteristics among the known hormonal inhibitors of gastric secretion.