Analysis of the CCL3-L1 gene for association with HIV-1 susceptibility and disease progression
Analysis of the CCL3-L1 gene for association with HIV-1 susceptibility and disease progression
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DOI：
10.1097/00002030-200404300-00017
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发表时间：
2004-04-30
期刊：
影响因子：
3.8
通讯作者：
Stewart, GJ
中科院分区：
文献类型：
--
作者：
Bugeja, MJ;Booth, DR;Stewart, GJ
CCL3-L1与CCR5的结合比任何其他趋化因子都更有效；它在体外抑制HIV-1感染，其基因以可变拷贝数出现，一些人无法产生它。我们分析了268名澳大利亚高加索人HIV-1患者和260名未感染的人中CCL3-L1缺失的频率。在HIV-1阴性个体中发现CCL3-L1阴性基因型频率为2.3%。未发现CCL3-L1缺失与HIV-1感染的易感性或进展速度之间存在关联。
CCL3-L1 binds more potently to CCR5 than any other chemokine; it inhibits HIV-1 infection in vitro, and its gene occurs in variable copy numbers, some individuals failing to produce it. We analysed the frequency of the absence of CCL3-L1 in 268 Caucasian Australian HIV-1 patients and 260 uninfected individuals. A CCL3-L1-negative genotype frequency of 2.3% was found in HIV-1-negative individuals. No association was found between the absence of CCL3-L1 and susceptibility to, or rate of progression of, HIV-1 infection.