Overactivity and structural changes in the chronically ischemic bladder
Overactivity and structural changes in the chronically ischemic bladder
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DOI：
10.1016/s0022-5347(05)68236-5
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发表时间：
1999-11-01
影响因子：
6.6
通讯作者：
Siroky, MB
中科院分区：
文献类型：
--
作者：
Azadzoi, KM;Tarcan, T;Siroky, MB
目的：研究慢性缺血对膀胱收缩和逼尿肌反应性的影响。材料和方法：雄性新西兰大白兔随机分为动脉损伤(AI)组、高胆固醇血症(HCH)组和对照组。AI组(n=18)球囊损伤髂动脉内皮细胞，给予0.5%胆固醇饮食。六氯环己烷组(n=8)仅给予0.5%的胆固醇饮食。对照组(n=8)给予常规饮食。16周后记录髂动脉和膀胱壁血流量。结果：16周时，铝组大鼠的髂动脉血流量明显低于六氯环己烷组和对照组。在Al组，8只动物出现重度膀胱缺血(SBI)，定义为膀胱血流量下降超过60%；7只动物出现中度膀胱缺血(MBI)，定义为膀胱血流量下降40%至60%；3只动物未出现明显的膀胱缺血(
Purpose: Our aim was to study the effect of chronic ischemia on bladder contraction and detrusor smooth muscle reactivity. The relationship between structural damage and functional changes in the chronically ischemic bladder was also investigated.Material and Methods: Male New Zealand White rabbits were divided into arterial injury (AI), hypercholesterolemia (Hch) and control groups. The AI group (n = 18) underwent balloon endothelial injury of the iliac arteries and received a 0.5% cholesterol diet. The Hch group (n = 8) received a 0.5% cholesterol diet alone. The control group (n = 8) received a regular diet. After 16 weeks, iliac artery and bladder wall blood flows were recorded. Cystometrograms and arteriography were obtained and bladder tissues were processed for isometric tension measurement in the organ bath and for histological evaluation.Results: At 16 weeks, blood flow through the iliac arteries was significantly reduced in the Al group compared with the Hch and control groups. In the Al group, 8 animals developed severe bladder ischemia (SBI) defined as greater than 60% decrease in bladder blood flow, 7 animals developed moderate bladder ischemia (MBI) defined as 40 to 60% decrease in bladder blood flow, and 3 animals failed to develop significant bladder ischemia (