Effects of plant stanol or sterol-enriched diets on lipid profiles in patients treated with statins: systematic review and meta-analysis.
Effects of plant stanol or sterol-enriched diets on lipid profiles in patients treated with statins: systematic review and meta-analysis.
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DOI：
10.1038/srep31337
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发表时间：
2016-08-19
影响因子：
4.6
通讯作者：
Qin L
中科院分区：
文献类型：
--
作者：
Han S;Jiao J;Xu J;Zimmermann D;Actis-Goretta L;Guan L;Zhao Y;Qin L
来自具有合适终点的试验的有效性和安全性数据表明，非他汀类药物与他汀类药物联合使用是进一步减少心血管事件的潜在策略。我们的目的是通过对随机对照试验(RCT)进行荟萃分析来评估强化斯坦醇或甾醇饮食对服用他汀类药物的患者的血脂谱的总体影响。我们使用PubMed、Cochrane图书馆和ClinicalTrials.gov数据库搜索截至2015年12月发表的文献。如果是随机对照试验，在他汀类药物治疗的患者中评估植物甾醇或甾醇的效果的试验也包括在分析中，这些试验报告了相应的血脂谱数据。我们包括15个随机对照试验，共涉及500名参与者。与单用他汀类药物相比，补充甾醇或甾醇的饮食与单用他汀类药物相比，可显著降低总胆固醇0.30 /L(95%CI−0.36至−0.25)和低密度脂蛋白胆固醇0.30 /L(95%CI−0.35至−0.25)，但对高密度脂蛋白胆固醇或甘油三酯无显著影响。这些结果在亚组分析中持续存在。我们的荟萃分析提供了进一步的证据表明，在接受他汀类药物治疗的患者中，补充斯坦醇或类固醇的饮食额外降低了总胆固醇和低密度脂蛋白-胆固醇水平，而不是单独服用他汀类药物。
Efficacy and safety data from trials with suitable endpoints have shown that non-statin medication in combination with a statin is a potential strategy to further reduce cardiovascular events. We aimed to evaluate the overall effect of stanol- or sterol-enriched diets on serum lipid profiles in patients treated with statins by conducting a meta-analysis of randomized controlled trials (RCTs). We used the PubMed, Cochrane library and ClinicalTrials.gov databases to search for literature published up to December 2015. Trials were included in the analysis if they were RCTs evaluating the effect of plant stanols or sterols in patients under statin therapy that reported corresponding data on serum lipid profiles. We included 15 RCTs involving a total of 500 participants. Stanol- or sterol-enriched diets in combination with statins, compared with statins alone, produced significant reductions in total cholesterol of 0.30 mmol/L (95% CI −0.36 to −0.25) and low-density lipoprotein (LDL) cholesterol of 0.30 mmol/L (95% CI −0.35 to −0.25), but not in high-density lipoprotein cholesterol or triglycerides. These results persisted in the subgroup analysis. Our meta-analysis provides further evidence that stanol- or sterol-enriched diets additionally lower total cholesterol and LDL-cholesterol levels in patients treated with statins beyond that achieved by statins alone.