SELECTION OF PATIENTS FOR RANDOMIZED CONTROLLED TRIALS - IMPLICATIONS OF WIDE OR NARROW ELIGIBILITY CRITERIA
SELECTION OF PATIENTS FOR RANDOMIZED CONTROLLED TRIALS - IMPLICATIONS OF WIDE OR NARROW ELIGIBILITY CRITERIA
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DOI：
10.1002/sim.4780090114
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发表时间：
1990-01-01
影响因子：
2
通讯作者：
TORETSKY, ER
中科院分区：
文献类型：
--
作者：
YUSUF, S;HELD, P;TORETSKY, ER
本文讨论了影响随机对照试验患者选择的各种哲学。虽然根据试验的不同，必须考虑一些不同的、往往相互竞争的问题，但保持进入标准简单、广泛，有时甚至灵活，通常是可取的。这种策略可以是一种积极的美德，因为它有助于以合理的成本获得通常需要的大量患者，以可靠地检测各种适度的益处，并提供与具有特定病症的许多不同类别患者相关的答案。
This paper discusses the various philosophies that influence the selection of patients for entry into randomized controlled trials. Although a number of different and often competing issues have to be considered depending upon the trial, keeping entry criteria simple, wide and at times even flexible is usually preferable. Such a strategy can be a positive virtue by helping to attain the large numbers of patients that are usually needed to reliably detect the sorts of moderate benefits that are plausible, at a reasonable cost and by providing answers that are relevant to many different categories of patients with a particular condition.