M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.
M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.
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M6A —Writer — 基因 METTL14：一种有利的预后生物标志物，与直肠癌免疫浸润相关
DOI：
10.3389/fonc.2021.615296
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zeng S
中科院分区：
文献类型：
--
作者：
Cai C;Long J;Huang Q;Han Y;Peng Y;Guo C;Liu S;Chen Y;Shen E;Long K;Wang X;Yu J;Shen H;Zeng S
直肠癌（RC）是男性和女性肿瘤相关死亡的主要原因。直肠癌免疫治疗的疗效与免疫浸润水平密切相关。N6-甲基腺苷（m6 A）修饰可能在肿瘤-免疫相互作用中发挥关键作用。然而，m6 A相关基因在直肠癌的肿瘤-免疫相互作用中的作用在很大程度上仍然未知。通过对m6 A相关基因的表达水平及其与直肠癌患者预后的相关性进行评估，我们发现胃L14是直肠癌患者中唯一与预后显著相关的基因。因此，我们进一步观察了直肠癌中胃L14表达和m6 A修饰对免疫浸润的影响。我们的研究表明，直肠癌中m6 A“writer”基因胃L14的低表达可能导致m6 A RNA修饰下调，从而降低免疫细胞浸润水平，导致预后不良。直肠癌组织中L14的表达水平与免疫浸润水平呈正相关，是直肠癌独立的预后因素。我们的研究确定了胃L14作为增强直肠癌免疫治疗疗效的潜在靶点。
Rectal cancer (RC) is the leading cause of tumor-related death among both men and women. The efficacy of immunotherapy for rectal cancer is closely related to the immune infiltration level. The N6-methyladenosine (m6A) modification may play a pivotal role in tumor-immune interactions. However, the roles of m6A-related genes in tumor-immune interactions of rectal cancer remain largely unknown. After an evaluation on the expression levels of m6A-related genes and their correlations with the prognosis of rectal cancer patients, we found that METTL14 was the only gene to be significantly correlated with prognosis in rectal cancer patients. Therefore, we further observed the impact of METTL14 expression and m6A modification on the immune infiltration in rectal cancer. Our study indicates that low expression of the m6A “writer” gene METTL14 in rectal cancer may lead to the downregulation of m6A RNA modification, thus reducing the level of immune cell infiltration and resulting in poor prognosis. METTL14 expression level is an independent prognostic factor in rectal cancer and is positively correlated with the immune infiltration level. Our study identified METTL14 as a potential target for enhancing immunotherapy efficacy in rectal cancer.
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影响因子：
28.2
作者：
Grasso CS;Giannakis M;Wells DK;Hamada T;Mu XJ;Quist M;Nowak JA;Nishihara R;Qian ZR;Inamura K;Morikawa T;Nosho K;Abril-Rodriguez G;Connolly C;Escuin-Ordinas H;Geybels MS;Grady WM;Hsu L;Hu-Lieskovan S;Huyghe JR;Kim YJ;Krystofinski P;Leiserson MDM;Montoya DJ;Nadel BB;Pellegrini M;Pritchard CC;Puig-Saus C;Quist EH;Raphael BJ;Salipante SJ;Shin DS;Shinbrot E;Shirts B;Shukla S;Stanford JL;Sun W;Tsoi J;Upfill-Brown A;Wheeler DA;Wu CJ;Yu M;Zaidi SH;Zaretsky JM;Gabriel SB;Lander ES;Garraway LA;Hudson TJ;Fuchs CS;Ribas A;Ogino S;Peters U
通讯作者：
Peters U
影响因子：
11.5
作者：
Governa, Valeria;Trella, Emanuele;Spagnoli, Giulio C.
通讯作者：
Spagnoli, Giulio C.
影响因子：
37.3
作者：
Chen, Xiaoxiang;Xu, Mu;Wang, Shukui
通讯作者：
Wang, Shukui
影响因子：
5.6
作者：
Lin, Hao-yu;Sun, Shu-ming;Peng, Chun-yan
通讯作者：
Peng, Chun-yan
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS