Randomized controlled trial assessing two commercial weight loss programs in adults with overweight or obesity
Randomized controlled trial assessing two commercial weight loss programs in adults with overweight or obesity
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DOI：
10.1002/osp4.312
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发表时间：
2019-02-01
影响因子：
2.2
通讯作者：
Cook, C. M.
中科院分区：
文献类型：
--
作者：
Arterburn, L. M.;Coleman, C. D.;Cook, C. M.
目的生活方式干预仍然是肥胖治疗的基石。商业计划提供了一种减肥方法，但很少有这样的计划的有效性进行了严格的调查。本研究的目的是评估两种商业减肥计划的有效性，这两种计划都使用预先分配的代餐（MR）和不同水平的行为支持，与超重和肥胖的成年人自我控制饮食相比。方法在这项为期16周的研究中，参与者被随机分配到低热量的OPTAVIA（R）5&1计划（R）与电话指导（OPT），低热量的Medifast（R）4&2&1自我指导计划（MED）或自我指导，低热量控制饮食。体重、身体成分（DXA）和身体围度的差异，每月测量一次，通过协方差分析进行评估，性别和基线测量作为协变量。结果在198名随机参与者中（80.8%为女性，BMI 34.2 kg/m2，45.7岁），92.3%完成了研究。OPT和MED组在体重（分别为-5.7%和-5.0%，p < 0.0001）、脂肪和腹部脂肪量（p <0.0001）以及腰围和臀围（p < 0.0001）方面的降幅明显更大。
Objective Lifestyle interventions remain the cornerstone for obesity treatment. Commercial programs offer one weight loss approach, yet the efficacy of few such programs have been rigorously investigated. The purpose of this study was to evaluate the efficacy of two commercial weight-loss programs, both utilizing pre-portioned meal replacements (MRs) and different levels of behavioural support, compared to a self-directed control diet in adults with overweight and obesity. Methods In this 16-week study, participants were randomized to the low-calorie OPTAVIA (R) 5&1 Plan (R) with telephone coaching (OPT), the reduced-calorie Medifast (R) 4&2&1 self-guided plan (MED), or a self-directed, reduced-calorie control diet. Differences in weight, body composition (DXA) and body circumferences, all measured monthly, were assessed by analysis of covariance with sex and baseline measures as covariates. Results Of 198 participants randomized (80.8% female, BMI 34.2 kg/m(2), 45.7 years), 92.3% completed the study. The OPT and MED groups had significantly greater reductions in body weight (-5.7% and - 5.0%, respectively, p < 0.0001), fat and abdominal fat mass (p < 0.0001) and waist and hip circumferences (p