A new osmium-191 leads to iridium-191m generator.
A new osmium-191 leads to iridium-191m generator.
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新的锇-191 导致铱-191m 发生器。
DOI：
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发表时间：
1980
影响因子：
9.3
通讯作者：
M. A. Davis
中科院分区：
文献类型：
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作者：
C. Cheng;S. Treves;A. Samuel;M. A. Davis
研制了一种适用于首过放射性核素心血管造影的锇-191生成铱-191m发生器。该发生器系统允许从其15.4天的Os- 191母体中重复洗脱4.96秒的铱-191m。将Os-191负载在阴离子交换柱（AGMP-1）上，并用0.9% NaCl在pH 1下洗脱Ir- 191m。发生器的每次洗脱（0.6至1ml）产生约7至10%的Ir-191m，并给出0.003-0.008%的Os-191突破。在动物身上进行的发生器洗脱液毒性研究支持在人类中使用铱-191m的安全性。发生器的长保质期（约等于2周）将允许医疗中心使用Ir- 191m进行常规临床诊断。用这种方法获得的铱-191m应该在核医学中找到其他有用的应用。
A new osmium-191 leads to iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os- 191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir- 191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003-0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (approximately equal to 2 wk) will allow medical centers to use Ir- 191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.