Septal cholinergic mediation of hippocampal theta in the cat
Septal cholinergic mediation of hippocampal theta in the cat
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DOI：
10.1016/s0361-9230(02)00797-9
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发表时间：
2002-07-01
影响因子：
3.8
通讯作者：
Konopacki, J
中科院分区：
文献类型：
--
作者：
Golebiewski, H;Eckersdorf, B;Konopacki, J
研究了在自由行为的猫体内微量注射毒菌碱（硫酸阿托品、匹伦齐平和胆碱）和烟碱（六甲氧铵）拮抗剂对自发性、感觉性和电诱导海马(HPC) θ脑电图活动的影响。六甲铵的施用未能对hpc θ产生可检测的影响。注射阿托品和吡仑西平可使其消失，而注射胆碱只可使海马θ减少。振幅和功率逐渐恢复，频率迅速恢复。我们的数据提供了进一步的证据，证明隔区M1和M2毒蕈碱受体亚型介导了该物种的HPC theta。脑膜内显微注射胆碱能激动剂（恰巴醇）可产生几乎连续的HPC θ波，且振幅和功率增加。我们还讨论了内侧间隔胆碱能投射对HPC θ频率和振幅的影响。(C) 2002爱思唯尔科学有限公司版权所有。
The effects of intraseptally microinjected muscarinic (atropine sulfate, pirenzepine and gallamine) and nicotinic (hexamethonium) antagonists on spontaneous, sensory and electrically-induced hippocampal (HPC) theta EEG activity were investigated in the freely behaving cat. Administration of hexamethonium failed to elicit a detectable effect on H PC theta. Injections of atropine and pirenzepine abolished, whereas the injection of gallamine only reduced hippocampal theta. Moreover, a gradual recovery of theta amplitude and power was observed, while frequency recovered rapidly. Our data provide further evidence that the septal M1 and M2 muscarinic receptor subtypes mediate the HPC theta in this species. Intraseptal microinjection of cholinergic agonist (carbachol) produced almost a continuous HPC theta with increased amplitude and power. The contribution of the medial septal cholinergic projections to HPC theta frequency and amplitude was also discussed. (C) 2002 Elsevier Science Inc. All rights reserved.