Satellite glia modulate sympathetic neuron survival, activity, and autonomic function.
Satellite glia modulate sympathetic neuron survival, activity, and autonomic function.
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卫星神经胶质调节交感神经元的生存，活性和自主功能。
DOI：
10.7554/elife.74295
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发表时间：
2022-08-23
期刊：
影响因子：
7.7
通讯作者：
Kuruvilla, Rejji
中科院分区：
文献类型：
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作者：
Mapps, Aurelia A.;Boehm, Erica;Beier, Corinne;Keenan, William T.;Langel, Jennifer;Liu, Michael;Thomsen, Michael B.;Hattar, Samer;Zhao, Haiqing;Tampakakis, Emmanouil;Kuruvilla, Rejji
卫星胶质细胞是交感神经节中的主要胶质细胞，包围神经元细胞体。尽管存在这种密切的关联，但体内卫星神经胶质细胞对交感神经功能的影响程度仍不清楚。在这里，我们发现卫星胶质细胞对于交感神经元的新陈代谢、生存和活动至关重要，并调节小鼠的自主行为。成人卫星胶质细胞的消融会导致 mTOR 信号传导受损、体细胞萎缩、去甲肾上腺素能酶减少和交感神经元丧失。然而，持续存在的神经元活性升高，卫星胶质细胞去除的小鼠表现出瞳孔扩张和心率增加，表明交感神经张力增强。卫星神经胶质细胞特异性删除 Kir4.1（一种内向整流钾通道）在很大程度上概括了在神经胶质细胞消融小鼠中观察到的细胞缺陷，表明卫星神经胶质细胞部分通过 K+ 依赖性机制发挥作用。这些发现强调神经元卫星胶质细胞作为调节交感神经输出的功能单位，对与交感神经过度活跃相关的疾病（例如心血管疾病和高血压）具有影响。
Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, the extent to which sympathetic functions are influenced by satellite glia in vivo remains unclear. Here, we show that satellite glia are critical for metabolism, survival, and activity of sympathetic neurons and modulate autonomic behaviors in mice. Adult ablation of satellite glia results in impaired mTOR signaling, soma atrophy, reduced noradrenergic enzymes, and loss of sympathetic neurons. However, persisting neurons have elevated activity, and satellite glia-ablated mice show increased pupil dilation and heart rate, indicative of enhanced sympathetic tone. Satellite glia-specific deletion of Kir4.1, an inward-rectifying potassium channel, largely recapitulates the cellular defects observed in glia-ablated mice, suggesting that satellite glia act in part via K+-dependent mechanisms. These findings highlight neuron–satellite glia as functional units in regulating sympathetic output, with implications for disorders linked to sympathetic hyper-activity such as cardiovascular disease and hypertension.