Assessment of Body Composition From CT Images at the Level of the Third Lumbar Vertebra in Inflammatory Bowel Disease
Assessment of Body Composition From CT Images at the Level of the Third Lumbar Vertebra in Inflammatory Bowel Disease
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DOI：
10.1093/ibd/izaa306
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发表时间：
2021-09-01
影响因子：
4.9
通讯作者：
Sasaki, Masaya
中科院分区：
文献类型：
--
作者：
Bamba, Shigeki;Inatomi, Osamu;Sasaki, Masaya
背景资料：虽然有几个报告的身体组成参数和炎症性肠病（IBD）患者的结果之间的关联，目前尚不清楚哪些肌肉组织参数和/或脂肪组织参数最强烈地影响结果。因此，本研究旨在确定这些参数的关联确定在第三腰椎（L3）的水平上的计算机断层扫描（CT）图像与结果在IBD patients.Methods：主题是IBD患者谁被收治到我们医院，并接受腹部CT。评估了以下参数：骨骼肌指数、腰大肌指数、内脏脂肪组织/身高指数、内脏与皮下脂肪组织面积比和肌内脂肪组织含量。在这项研究中，短期和长期的结果被定义为延长住院时间（30天）和肠切除术在整个观察期间，分别为：结果，共187例患者，99克罗恩病和88溃疡性结肠炎。对所有IBD患者进行多因素Logistic回归分析，发现入院时低白蛋白水平和低腰大肌指数与住院时间延长相关。多因素考克斯回归分析显示，男性、克罗恩病（非溃疡性结肠炎）、腰大肌指数低和内脏与皮下脂肪组织面积比高与肠切除相关。这项研究表明，肌肉体积与长期住院的短期结果有关，而肌肉体积和内脏脂肪组织体积（相对于皮下脂肪组织体积）与肠切除术的长期结果相关。
Background: Although there are several reports of associations between body composition parameters and outcomes in patients with inflammatory bowel disease (IBD), it is not clear which muscle tissue parameters and/or adipose tissue parameters most strongly affect outcomes. Therefore, this study sought to determine the associations of such parameters determined at the level of the third lumbar vertebra (L3) on computed tomography (CT) images with outcomes in IBD patients.Methods: Subjects were IBD patients who were admitted to our hospital and underwent abdominal CT. The following parameters were assessed: skeletal muscle index, psoas muscle index, visceral adipose tissue/height index, visceral to subcutaneous adipose tissue area ratio, and intramuscular adipose tissue content. In this study, short- and long-term outcomes were defined as prolonged length of stay (30 days) and intestinal resection during the overall period of observation, respectively.Results: In total, 187 patients were enrolled, 99 with Crohn's disease and 88 with ulcerative colitis. For all IBD patients, multivariate logistic regression analysis revealed that low albumin level and low psoas muscle index on admission were associated with prolonged length of stay. Multivariate Cox regression analysis revealed that male sex, Crohn's disease (not ulcerative colitis), low psoas muscle index, and high visceral to subcutaneous adipose tissue area ratio were associated with intestinal resection.Conclusions: This study revealed that muscle volume is associated with the short-term outcome of prolonged length of stay, whereas muscle volume and visceral adipose tissue volume (relative to subcutaneous adipose tissue volume) are associated with the long-term outcome of intestinal resection.