Regulation of cerebral oxygen delivery.
Regulation of cerebral oxygen delivery.
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脑氧输送的调节。
DOI：
10.1007/978-1-4615-4717-4_12
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发表时间：
1999
影响因子：
--
通讯作者：
Rothman,DL
中科院分区：
文献类型：
--
作者：
Hyder,F;Shulman,RG;Rothman,DL
在正常条件下，一般认为，对于成年哺乳动物皮层，几乎所有脑ATP生成所需的能量都是通过三羧酸循环氧化葡萄糖提供的（Siesjö，1978），而氧和葡萄糖使用的脑代谢率（即，CMR 02和CMRglc）被局部修饰以通过调节脑血流量（CBF）和容量（CBV）来满足代谢需要（Roy和Sherrington，1890）。然而，一些正电子发射断层扫描（PET）结果已经报道，在清醒的人类的脑激活期间，CBF比CMRO 2增加更大的分数（Fox和Raichle，1986; Fox等人，1988年）。在过去的几十年里，自从活体皮质测量可以CBF和/或CMRO 2，CBF和CMRO 2之间的变化比例的机制，由于生理扰动仍然是无形的，和测量的化学计量变化，反映了各种实验方法和/或条件。然而，在休息时观察到CMRO 2和CBF之间的区域紧密关系，比率约为1：1（凯蒂等人，1947-8; Raichle等人，1976年）。
Under normal conditions, it is generally accepted that for the adult mammalian cortex, almost all the energy required for cerebral ATP generation is supplied by oxidation of glucose through the tri-carboxylic acid cycle (Siesjö, 1978), and cerebral metabolic rates of oxygen and glucose use (i.e., CMRO2and CMRglc, respectively) are regionally modified to fulfil metabolic needs through regulation of cerebral blood flow (CBF) and volume (CBV) (Roy and Sherrington, 1890). However, some positron emission tomography (PET) results have reported that during brain activation of awake humans CBF increases by a greater fraction than CMRO2(Fox and Raichle, 1986; Fox et al., 1988). In the last few decades, ever sincein vivocortical measurements could be made of CBF and/or CMRO2, the mechanisms for the proportionality of changes between CBF and CMRO2due to physiological perturbations have remained intangible, and the measured stoichiometries have varied reflecting a variety of experimental methods and/or conditions. However, regionally tight relationship between CMRO2and CBF has been observed at rest with a ratio of about ~1:1 (Kety et al., 1947–8; Raichle et al., 1976).