Gene flow of unique sequences between Mus musculus domesticus and Mus spretus
Gene flow of unique sequences between Mus musculus domesticus and Mus spretus
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DOI：
10.1007/s003350010041
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发表时间：
2000-03-01
期刊：
影响因子：
2.5
通讯作者：
Hardies, SC
中科院分区：
文献类型：
--
作者：
Greene-Till, R;Zhao, YP;Hardies, SC
通过在453-bp的独特序列位点处测序，已经从各种小家鼠亚种和小家鼠品系中检查了等位基因多样性。一个M M. C57 BL/KsJ与M. spretus野生衍生近交系SEG和其他野生M. spretus分离物。除非存在种间基因流动，否则物种之间的预期分化应该排除这种结果。C57 BL/KsJ对M. spretus特异性重复序列表明它既不是错误鉴定的spretus菌株，也不是spretus/spretus杂种。因此，除了先前报道的存在少量的小家鼠特异性重复DNA在M。in.在这两个物种之间，有一种可检测到的独特序列流。在spretus等位基因中也观察到了祖先的多态性。讨论了区分祖先多态性和水平迁移的困难。
Allelic diversity has been examined from a variety of Mus musculus subspecies and Mus spretus strains by sequencing at a 453-bp unique sequence locus. One M. m. domesticus classic inbred strain, C57BL/KsJ, contained a sequence identical to that in the M. spretus wild-derived inbred strain SEG, and other wild M. spretus isolates. Such a result should have been precluded by the expected divergence between the species unless there has been interspecies gene flow. Examination of C57BL/KsJ for M. spretus-specific repetitive sequences shows that it is neither a misidentified spretus strain nor a domesticus/spretus hybrid. Thus, in addition to the previously reported presence of small amounts of Mus spretus-specific repetitive DNA in M. in. domesticus, there is a detectable flow of unique sequence between the two species. There was also ancestral polymorphism observed among the spretus alleles. The difficulty of distinguishing ancestral polymorphism from horizontal transfer is discussed.