Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation
Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation
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DOI：
10.1088/0031-9155/58/10/3243
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发表时间：
2013-05-21
影响因子：
3.5
通讯作者：
Schaart, Dennis R.
中科院分区：
文献类型：
--
作者：
van Dam, Herman T.;Borghi, Giacomo;Schaart, Dennis R.
数字硅光电倍增管（dSiPM）阵列具有良好的特性，可用于飞行时间正电子发射断层扫描（PET）的单片闪烁体探测器。为了充分利用这些益处，开发了最大似然相互作用时间估计（MLITE）方法，以从每个闪烁事件获得的多个时间戳中推导出相互作用的时间。MLITE与几种确定性方法进行了比较。使用基于新型dSiPM阵列和16 x 16 x 10 mm（3）、16 x 16 x 20 mm（3）、24 x 24 x 10 mm（3）和24 x 24 x 20 mm（3）的LSO：Ce，0.2%Ca晶体的单片闪烁体探测器进行定时测量。最佳符合分辨时间（CRT）的对相同的探测器获得与MLITE和测量157 ps，185 ps，161 ps，和184 ps的半高全宽（FWHM），分别。为了进行比较，由耦合到dSiPM阵列的单个像素的3 x 3 x 5 mm（3）LSO：Ce，0.2%Ca晶体组成的小型参考检测器被测量为具有低至120 ps FWHM的CRT。这项工作的结果表明，闪烁光子的光学传输对单片闪烁体探测器的定时性能的影响可以至少部分地通过利用包含在每个闪烁事件记录的时间戳的集合的时空分布中的信息来校正。
Digital silicon photomultiplier (dSiPM) arrays have favorable characteristics for application in monolithic scintillator detectors for time-of-flight positron emission tomography (PET). To fully exploit these benefits, a maximum likelihood interaction time estimation (MLITE) method was developed to derive the time of interaction from the multiple time stamps obtained per scintillation event. MLITE was compared to several deterministic methods. Timing measurements were performed with monolithic scintillator detectors based on novel dSiPM arrays and LSO:Ce, 0.2%Ca crystals of 16 x 16 x 10 mm(3), 16 x 16 x 20 mm(3), 24 x 24 x 10 mm(3), and 24 x 24 x 20 mm(3). The best coincidence resolving times (CRTs) for pairs of identical detectors were obtained with MLITE and measured 157 ps, 185 ps, 161 ps, and 184 ps full-width-at-half-maximum (FWHM), respectively. For comparison, a small reference detector, consisting of a 3 x 3 x 5 mm(3) LSO: Ce, 0.2%Ca crystal coupled to a single pixel of a dSiPM array, was measured to have a CRT as low as 120 ps FWHM. The results of this work indicate that the influence of the optical transport of the scintillation photons on the timing performance of monolithic scintillator detectors can at least partially be corrected for by utilizing the information contained in the spatio-temporal distribution of the collection of time stamps registered per scintillation event.