The relationship between B-type natriuretic peptide and health status in patients with heart failure
The relationship between B-type natriuretic peptide and health status in patients with heart failure
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DOI：
10.1016/j.cardfail.2005.02.004
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发表时间：
2005-08-01
影响因子：
6
通讯作者：
Masoudi, FA
中科院分区：
文献类型：
--
作者：
Luther, SA;McCullough, PA;Masoudi, FA
背景资料：虽然B型利钠肽（BNP）水平已被提出作为一种手段，评估疾病的严重程度，在心力衰竭患者。尚不清楚BNP水平是否与健康状况（症状负担、功能限制和生活质量）相关。方法和结果：我们研究了来自14个中心的342名患有收缩性心力衰竭的门诊患者的基线和6 +/-2周BNP水平和堪萨斯城心脏病量表（KCCQ）。一种专门针对心力衰竭的健康状况工具。我们评估了KCCQ评分和基线BNP之间的相关性，并根据基线和随访期间BNP水平的变化评估了KCCQ的变化。平均基线BNP水平为379 ± 387 pg/mL，平均KCCQ汇总核心评分为62 ± 23分。尽管基线BNP和KCCQ均与纽约心脏协会分级相关（P <50% BNP变化阈值，BNR降低的患者KCCQ改善3.7 ± 14.2，BNP无变化的患者KCCQ改善1.7 ± 13.6。结论：BNP与健康状况在短期内无相关性，提示这些指标可以从不同方面评估心力衰竭的严重程度，而生理指标不能反映患者对心力衰竭对其健康状况的影响。
Background: Although B-type natriurefic peptide (BNP) levels have been proposed as a means of assessing disease severity in patients with heart failure. it is not known if BNP levels are correlated with health status (symptom burden, functional limitation, and quality of life),Methods and Results: We studied 342 outpatients with systolic heart failure from 14 centers at baseline and 6 +/- 2 weeks with BNP levels and the Kansas City Cardioniyopathy Questionaire (KCCQ). a heart-failure-specific health status instrument. We assessed the correlation between KCCQ scores and BNP at baseline and changes in KCCQ according to changes in BNP levels between baseline and follow-up, Mean baseline BNP levels were 379 +/- 387 pg/mL and mean KCCQ summary,cores were 62 2 23 points. Although baseline BNP and KCCQ were both associated with New York Heart Association classification (P 50% BNP change threshold, KCCQ improved by 3.7 +/- 14.2 in patients with decreasing BNR improved by 1.7 +/- 13.6 in patients with no BNP change. and improved by 1.0 +/- 13.4 in patients with increasing BNP (P =.6).Conclusion: BNP and health status are not correlated in outpatients with heart failure in the short term, This suggests that these measures may assess different aspects of heart failure severity, and that physiologic measures do not reflect patients ' perceptions of the impact of heart failure on their health status.