EFFECTS OF ANTIHISTAMINES ON JOINT STIFFNESS AND BONE HEALING AFTER PERIARTICULAR FRACTURE
EFFECTS OF ANTIHISTAMINES ON JOINT STIFFNESS AND BONE HEALING AFTER PERIARTICULAR FRACTURE
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DOI：
10.1016/0363-5023(93)90406-s
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发表时间：
1993-11-01
影响因子：
1.9
通讯作者：
MEALS, RA
中科院分区：
文献类型：
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作者：
GEBHARD, JS;JOHNSTONJONES, K;MEALS, RA
为了减轻损伤后的炎症反应，我们研究了抗组胺药物对关节僵硬和关节周围骨折后骨愈合的影响。37只新西兰大白兔的后肢在造成胫骨远端骨折后，用Steinmann髓内钉固定。关节周围骨折后，将兔分为氯苯那明、小剂量特非那定、大剂量特非那定或不使用抗组胺药组。骨折后前5天给予抗组胺药物治疗。在骨折后3周，接受抗组胺药物治疗的兔与对照组相比关节僵硬显著降低。为了确定抗组胺药是否也延缓了骨愈合，另外12只新西兰白兔接受了用2.5 mm的Steinmann钉在双侧股骨中段钻孔。6只动物接受了特非那定的口服。另有6人作为对照。笼子活动5周后，经抗组胺治疗的动物在扭转测试中股骨断裂的能量显著降低。定性显微镜检查显示，特非那定治疗的动物股骨皮质缺损处的骨痂成熟程度较低。到目前为止，抗组胺药在预防创伤后关节僵硬方面可能有尚未考虑到的好处，但可能会减缓相关骨骼损伤的愈合。
In an effort to blunt the inflammatory response following injury, we studied the effects of antihistamines on joint stiffness and bone healing after periarticular fracture. The hind limbs of 37 New Zealand white rabbits were instrumented with intramedullary Steinmann pins to allow immobilization after creating a distal tibia fracture. After periarticular ankle fracture, the rabbits were divided into groups to receive chlorpheniramine, low-dose terfenadine, high-dose terfenadine, or no antihistamine. Antihistamine was administered for the first 5 days after fracture. At 3 weeks after fracture, the rabbits treated with antihistamines showed a significant reduction in joint stiffness compared to control animals. To determine if antihistamine also retarded bone healing, an additional 12 New Zealand white rabbits underwent bilateral drilling of the midshaft of the femur with a 2.5 mm Steinmann pin. Six animals received oral terfenadine. and six served as controls. After 5 weeks of cage activity, the animals treated with the antihistamine showed a significant decrease in energy to failure of the femurs on torsional testing. Qualitative microscopic examination revealed less mature callus at the site of the femoral cortical defect in those animals treated with the terfenadine. Antihistamine may have heretofore unconsidered benefits in preventing post-traumatic joint stiffness but may slow healing of associated bony injuries.