DIET, SERUM MARKERS AND BREAST-CANCER MORTALITY IN CHINA
DIET, SERUM MARKERS AND BREAST-CANCER MORTALITY IN CHINA
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DOI：
10.1111/j.1349-7006.1994.tb02398.x
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发表时间：
1994-06-01
期刊：
影响因子：
--
通讯作者：
BLOT, WJ
中科院分区：
文献类型：
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作者：
GUO, WD;CHOW, WH;BLOT, WJ
这项基于县的相关性研究利用从中国65个农村县的生态调查中收集的数据，研究了乳腺癌死亡率与饮食习惯和某些血清生化标志物的关系。单因素相关分析和多因素回归分析显示，动物性食品（包括蛋、鱼和肉）的消费与中国妇女乳腺癌死亡率呈显著正相关。在这项研究中，没有观察到乳腺癌死亡率与绿色蔬菜、胡萝卜和水果的消费之间存在明显的联系。观察到血清维生素C水平与乳腺癌死亡率之间存在适度的负相关，而硒水平与死亡率呈正相关。发现血清铁蛋白和血红蛋白呈正相关，这与最近的报告一致，即癌症风险升高与体内铁储存增加有关。这些生态数据的局限性排除了因果关系的推断，但这些发现为世界低发病率地区的乳腺癌风险和保护因素提供了线索。
This county-based correlation study examined associations of breast cancer mortality with dietary habits and certain serum biochemical markers, utilizing data collected from an ecological survey in 65 Chinese rural counties. Univariate correlation and multivariate regression analysis showed that consumption of animal foods, including eggs, fish and meat, was positively linked to county-wide mortality rates of breast cancer in Chinese women. No clear associations between breast cancer mortality rates and consumption of green vegetables, carrots and fruits were observed in this study. A modest inverse correlation between serum vitamin C levels and breast cancer mortality was observed, while selenium levels were positively related to the mortality rates. Positive correlations for serum ferritin and hemoglobin were found, in agreement with recent reports of an elevated cancer risk with increased body iron stores. Limitations of these ecological data preclude causal inferences, but the findings provide clues to breast cancer risk and protective factors in a low incidence area of the world.