QUANTITATIVE ANALYSIS OF CYSTOID MACULAR EDEMA USING SCANNING LASER OPHTHALMOSCOPE IN MODIFIED DARK-FIELD IMAGING
QUANTITATIVE ANALYSIS OF CYSTOID MACULAR EDEMA USING SCANNING LASER OPHTHALMOSCOPE IN MODIFIED DARK-FIELD IMAGING
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DOI：
10.1097/iae.0b013e3182497141
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发表时间：
2012-10
期刊：
影响因子：
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通讯作者：
Takashi Katome;Y. Mitamura;Toshihiko Nagasawa;H. Eguchi;T. Naito
中科院分区：
文献类型：
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作者：
Takashi Katome;Y. Mitamura;Toshihiko Nagasawa;H. Eguchi;T. Naito
目的：应用激光扫描检眼镜对黄斑囊样水肿(CME)进行定量分析。方法：对37只合并不同疾病的CME患者治疗前后的临床资料进行分析。用改良暗视野成像和荧光素血管造影术测量CME面积。用Humphrey全自动视野计测量最佳矫正视力、平均偏差和黄斑敏感度，用光学相干断层扫描测量黄斑中心凹厚度和黄斑体积。结果：荧光素血管造影术和改良暗视野造影术均能清晰显示CME区，分别为50%和100%(P<；0.0001)。改良暗视野成像计算的CME面积与荧光素血管造影计算的CME面积显著相关(P=0.0001)。治疗前，仅黄斑体积与改良暗视野成像计算的CME面积显著相关(P=0.0230)。治疗三个月后，CME面积的减少与最佳矫正视力、平均偏差、黄斑敏感度、黄斑中心凹厚度和黄斑体积的改善显著相关(均为P<；0.05)。结论：激光扫描检眼镜在改良暗视野成像中可以测量CME的面积，对CME的定量分析有一定的参考价值。这些发现也可以用来评估治疗的有效性。
Purpose: To quantitatively analyze cystoid macular edema (CME) using scanning laser ophthalmoscope in the modified dark-field imaging. Methods: We studied 37 eyes with CME associated with different diseases before and after treatment. The CME area was measured with the modified dark-field imaging and fluorescein angiography. The best-corrected visual acuity, mean deviation and macular sensitivity measured by Humphrey automated perimetry, and foveal thickness and macular volume determined by optical coherence tomography were investigated. Results: The CME area could be clearly outlined in 50% with the fluorescein angiography and in 100% with the modified dark-field imaging (P < 0.0001). The CME area calculated using the modified dark-field imaging was significantly correlated with that using the fluorescein angiography (P = 0.0001). Before treatment, the CME area calculated using the modified dark-field imaging was significantly correlated with only the macular volume (P = 0.0230). Three months after treatment, decrease in the CME area was significantly correlated with improvement in the best-corrected visual acuity, mean deviation, macular sensitivity, foveal thickness, and macular volume (P < 0.05 for all). Conclusion: Our findings indicate that scanning laser ophthalmoscope in the modified dark-field imaging can measure the CME area and is useful in analyzing CME quantitatively. The findings can also be used to evaluate the effectiveness of treatment.