Environment and women's reproductive health
Environment and women's reproductive health
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DOI：
10.1093/humupd/dmq061
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发表时间：
2011-05-01
影响因子：
13.3
通讯作者：
Moscarini, M.
中科院分区：
文献类型：
--
作者：
Caserta, D.;Mantovani, A.;Moscarini, M.
背景：有重要证据表明，持续和长期接触几种内分泌干扰物(EDC)是女性生育力和生育力下降的危险因素。也有证据表明，ED暴露会产生跨代影响。在这一系统的综述中，我们评估了EDC暴露与女性生殖健康之间存在关联的证据。方法：通过在PubMed数据库中搜索2010年前发表的文章来寻找研究。PubMed数据库中报告的ED暴露与女性生殖健康之间的关系被总结并归类为生育力和生育力、妊娠结局、跨代暴露和影响。结果：关于EDCs的流行病学研究并不总是一致的，部分原因是由于实际限制的限制。为了在这一领域取得进展，我们建议利用生物监测和生物库，包括开发适当的生物标记物，并更多地考虑遗传多态和饮食习惯等调节因素。有必要进行进一步的人体研究，特别关注与目前普遍存在的勃起功能障碍(如双酚A、邻苯二甲酸盐和多溴阻燃剂)相关的生育力/生殖力受损。结论：对与不良生殖结局具体相关的化合物进行详细评估，对于预防和风险沟通策略非常重要。除了研究需要，目前的证据足以促使采取预防行动，保护妇女的生殖健康。
BACKGROUND: There is significant evidence that continuous and prolonged exposure to several endocrine disrupting chemicals (EDC) is a risk factor for reduced fertility and fecundity in women. There is also evidence that ED exposure has trans-generational effects. In this systematic review, we evaluate the evidence for an association between EDC exposure and women's reproductive health.METHODS: Studies were found by searching the PubMed database for articles published up to 2010. Associations between ED exposure and women's reproductive health reported in the PubMed database are summarized and classified as fertility and fecundity, pregnancy outcomes, transgenerational exposure and effects.RESULTS: Epidemiological studies on EDCs are not always consistent, in part due to limitations imposed by practical constraints. In order to make progress in this field, we recommend taking advantage of biomonitoring and biobanks, including the development of appropriate biomarkers, and taking into greater consideration modulating factors such as genetic polymorphisms and dietary habits. Further human studies are warranted with particular focus on impaired fertility/fecundity associated with currently widespread ED (e.g. bisphenol A, phthalates and polybrominated flame retardants).CONCLUSIONS: A detailed appraisal of compounds specifically related to adverse reproductive outcomes is very important for prevention and risk-communication strategies. Besides research needs, the current evidence is sufficient to prompt precautionary actions to protect women's reproductive health.