The Utility of Sono-Guided Sclerotherapy for Benign Thyroid Cyst: Prospective Study
The Utility of Sono-Guided Sclerotherapy for Benign Thyroid Cyst: Prospective Study
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声波引导硬化疗法治疗良性甲状腺囊肿的实用性：前瞻性研究
DOI：
10.3342/kjorl-hns.2012.55.12.777
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Seung Won Lee
中科院分区：
文献类型：
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作者：
S. Oh;Jeong Yeop Lee;Do Hoon Lee;Il Ha Moon;Ki Nam Kwon;K. Park;Seung Won Lee
2012年9月17日修订2012年11月27日接受2012年11月30日耳鼻喉科医学博士李承元的通讯地址顺春乡大学医学院富川医院头颈外科170 Jomaru-ro，Wonmi-gu，Bucheon 420-767，Korea电话：+82-32-621-5443传真：+82-32-621-5440电子邮件：lsw0922@schmc.ac.kr背景和目的ZZ超声(USG)引导下的硬化剂治疗甲状腺良性结节最近已成为治疗无功能良性甲状腺结节的常用方法。这项研究评估了USG引导下的硬化治疗的有效性和安全性。研究对象和方法ZZ纳入23例甲状腺囊性结节压迫或美容问题的患者，经细针吸取活检和甲状腺功能检查确诊为良性和无功能。在几乎完全排出甲状腺结节囊性部分的液体后，用OK-432或99.9%乙醇进行硬化治疗。在每次USG随访时，我们在术后1个月和6个月时测量囊肿量、症状评分、使用视觉模拟评分的美容评分以及相关并发症。结果术后6个月，甲状腺囊肿体积明显缩小(P<0.01)，平均缩小率为77.3±21.2%。硬化治疗后患者的美容评分和症状评分均有显著改善(p<；0.01)。随访观察未见声带麻痹、甲状腺功能亢进、组织坏死等与硬化治疗相关的主要并发症。结论ZZUSG引导下硬化治疗甲状腺良性囊性结节是一种简单、有效的治疗方法。韩国耳鼻咽喉-头颈部外科手术2012；55：777-81
Received September 17, 2012 Revised November 27, 2012 Accepted November 30, 2012 Address for correspondence Seung Won Lee, MD Department of OtolaryngologyHead and Neck Surgery, Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea Tel +82-32-621-5443 Fax +82-32-621-5440 E-mail lsw0922@schmc.ac.kr Background and ObjectivesZZUltrasonography (USG)-guided sclerotherapy using a sclerotherapic agent such as ethanol, OK-432, recently has gained popularity as a treatment for nonfunctioning benign thyroid nodules. The study evaluates the efficacy and safety of the USG-guided sclerotherapy for that purpose. Subjects and MethodZZIncluded in the study were 23 patients who had complaints of applied pressure or cosmetic problems due to cystic thyroid nodules, which had been diagnosed as benign and nonfunctioning by fine-needle aspiration biopsy and thyroid function test. Sclerotherapy was performed with OK-432 or 99.9% ethanol following nearly complete evacuation of the fluid from the cystic portion of thyroid nodule. At each USG follow-up, we measured the volume of cysts, symptom scores, cosmetic scores using a visual analog scale, and related complications were examined at postoperative dates of one and six months. ResultsZZThe volume of thyroid cysts were significantly reduced (p<0.01) with mean volume reduction rates of 77.3±21.2% at postoperative 6 months. The cosmetic score and symptom score were significantly improved following sclerotherapy (p<0.01). Major complications related to sclerotherapy, such as vocal cord paralysis, thyrotoxicosis and tissue necrosis, did not happen during the follow-up observation. ConclusionZZUSG-guided sclerotherapy could be a simple and effective treatment modality for benign cystic thyroid nodules. Korean J Otorhinolaryngol-Head Neck Surg 2012;55:777-81