Efficient experimental designs for isotropic generalized diffusion tensor MRI (IGDTI)
Efficient experimental designs for isotropic generalized diffusion tensor MRI (IGDTI)
复制标题
DOI：
10.1002/mrm.26656
复制
发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Basser, Peter J.
中科院分区：
文献类型：
--
作者：
Avram, Alexandru V.;Sarlls, Joelle E.;Basser, Peter J.
目的提出一种新的广义扩散张量成像（GDTI）实验设计和分析框架，用于有效测量方向平均扩散加权图像（DWI），去除由于扩散各向异性引起的体信号调制，量化各向同性高阶扩散张量（HOT）。我们说明了这个框架如何加速来自HOT，如HOT-跟踪和平均t-峰度的旋转不变的组织微观结构参数的临床测量。Theory and MethodsFor a large range of b-values，我们比较取向平均DWI测量与高角分辨率扩散成像与建议各向同性GDTI（IGDTI）实验设计获得的。我们比较旋转不变的微结构参数测量IGDTI那些来自HOTs明确测量GDTI.ResultsIn固定脑显微成像和在体临床实验，IGDTI可在广泛的b值范围内准确量化平均表观弥散系数（mADC）加权DWI，并可有效计算HOT。导出标量组织参数从少量的DWIS.ConclusionsIGDTI提供了直接和准确的估计取向平均组织水迁移率在很宽的范围内的b值。这种有效的方法可以使新的，灵敏的，定量的评估，其中可以观察到mADC的变化，如检测和表征中风，癌症和神经退行性疾病的临床应用。Magn Reson Med 79：180-194，2018。2017年出版。本条目属于美国政府作品，在美国属于公有领域。
PurposeWe propose a new generalized diffusion tensor imaging (GDTI) experimental design and analysis framework for efficiently measuring orientationally averaged diffusion-weighted images (DWIs), which remove bulk signal modulations attributed to diffusion anisotropy and quantify isotropic higher-order diffusion tensors (HOT). We illustrate how this framework accelerates the clinical measurement of rotation-invariant tissue microstructural parameters derived from HOT, such as the HOT-Trace and the mean t-kurtosis.Theory and MethodsFor a large range of b-values, we compare orientationally averaged DWIs measured with high angular resolution diffusion imaging to those obtained with the proposed isotropic GDTI (IGDTI) experimental design. We compare rotation-invariant microstructural parameters measured with IGDTI to those derived from HOTs measured explicitly with GDTI.ResultsIn both fixed-brain microimaging and in vivo clinical experiments, IGDTI accurately quantifies mean apparent diffusion coefficient (mADC)-weighted DWIs over a wide range of b-values and allows efficient computation of HOT-derived scalar tissue parameters from a small number of DWIs.ConclusionsIGDTI provides direct and accurate estimates of orientationally averaged tissue water mobilities over a wide range of b-values. This efficient method may enable new, sensitive, and quantitative assessments for clinical applications in which changes in mADC can be observe,d such as detecting and characterizing stroke, cancers, and neurodegenerative diseases. Magn Reson Med 79:180-194, 2018. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.