Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia:: results from a detailed genetic characterization with long-term follow-up
Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia:: results from a detailed genetic characterization with long-term follow-up
复制标题
DOI：
10.1182/blood-2008-04-154070
复制
发表时间：
2008-10-15
期刊：
影响因子：
20.3
通讯作者：
Stilgenbauer, Stephan
中科院分区：
文献类型：
--
作者：
Zenz, Thorsten;Kroeber, Alexander;Stilgenbauer, Stephan
在CLL中，TP53突变(无17p缺失)的确切预后作用以及缺失对CLL的影响尚不清楚。我们研究了126例特征良好的CLL患者，通过直接测序和DHPLC检测TP53突变(外显子2-11)。大多数17p缺失的患者还存在TP53突变(81%)。无17p缺失突变的发生率为4.5%。我们发现，携带TP53突变的患者生存期较短(n=18；P=0.002)，从突变检测的时间点分析，这种情况更为明显(6.8个月比69个月，P
The exact prognostic role of TP53 mutations (without 17p deletion) and any impact of the deletion without TP53 mutation in CLL are unclear. We studied 126 well-characterized CLL patients by direct sequencing and DHPLC to detect TP53 mutations (exons 2-11). Most patients with 17p deletions also had TP53 mutations (81%). Mutations in the absence of 17p deletions were found in 4.5%. We found a shorter survival for patients with TP53 mutation (n = 18; P = .002), which was more pronounced when analyzed from the time point of mutation detection (6.8 vs 69 months, P