Surgical incision induces anxiety-like behavior and amygdala sensitization: effects of morphine and gabapentin.
Surgical incision induces anxiety-like behavior and amygdala sensitization: effects of morphine and gabapentin.
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手术切口诱发焦虑样行为和杏仁核敏化：吗啡和加巴喷丁的作用
DOI：
10.1155/2010/705874
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发表时间：
2010
影响因子：
--
通讯作者：
Zhou XF
中科院分区：
文献类型：
--
作者：
Li CQ;Zhang JW;Dai RP;Wang J;Luo XG;Zhou XF
情感维度在术后疼痛中的作用仍然知之甚少。本研究调查了切口痛中焦虑样行为和杏仁核敏化的发展。在大鼠后爪切开模型上，通过高架正迷宫和开场实验，我们发现手术切开可以引起焦虑样行为。腹腔注射(Ip)吗啡以剂量依赖的方式逆转机械性痛觉异常和焦虑样行为。加巴喷丁还以剂量依赖的方式部分减少了切口诱发的机械性超敏和焦虑样行为。切开后，双侧杏仁核中央核和基底外侧核中磷酸化cAMP反应元件结合蛋白(p-CREB)的表达一过性上调。吗啡和加巴喷丁可抑制p-CREB的上调。本研究提示，手术切开可引起焦虑和杏仁核敏化，而吗啡和加巴喷丁可抑制这一作用。因此，用吗啡和加巴喷丁治疗手术引起的情感障碍可能是术后疼痛管理的一种潜在的重要辅助治疗方法。
The role of affective dimension in the postoperative pain is still poorly understood. The present study investigated the development of anxiety-like behavior and amygdala sensitization in incisional pain. Using hind-paw incision model in rats, we showed that surgical incision induced the anxiety-like behavior as determined by elevated plus-maze and open-field tests. Intraperitoneal (IP) morphine administration reversed mechanical allodynia and anxiety-like behavior in a dose-dependent manner. Gabapentin also partially reduced incision-evoked mechanical allodynia and anxiety-like behavior in a dose-dependent manner. After incision, the expression of phosphorylated cAMP response elements (CRE-) binding protein (p-CREB) was transiently upregulated in the central and basolateral nuclei in the bilateral amygdala. The upregulation of p-CREB was inhibited by morphine and gabapentin. The present study suggested that surgical incision could induce anxiety and amygdala sensitization that can be inhibited by morphine and gabapentin. Thus treatment of surgery-induced affective disturbances by morphine and gabapentin may be a potential important adjunct therapy in the postoperative pain management.