Pulsatile insulin secretion: Detection, regulation, and role in diabetes
Pulsatile insulin secretion: Detection, regulation, and role in diabetes
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DOI：
10.2337/diabetes.51.2007.s245
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发表时间：
2002-02-01
期刊：
影响因子：
7.7
通讯作者：
Schmitz, O
中科院分区：
文献类型：
--
作者：
Porksen, N;Hollingdal, M;Schmitz, O
胰岛素浓度周期性振荡，每次振荡5-15分钟。这些振荡是由于数以百万计的胰岛协调胰岛素分泌爆发造成的。共同分泌爆发的产生需要强大的胰岛内和胰腺内的协调，以同步β细胞爆发群的分泌活动。这种搏动机制的总体贡献占主导地位，并占胰岛素释放的大部分。本文综述了检测和定量周期性和个体分泌爆发的方法。本文讨论了通过神经、代谢物、激素和药物的搏动成分的变化来调节胰岛素分泌的机制：2型糖尿病患者的胰岛素搏动分泌受损导致了对胰岛素传递模式对胰岛素作用影响的关注，并证明了振荡胰岛素暴露对肝脏、肌肉和脂肪组织的改善作用。因此，胰岛素的主导调节不仅是通过分泌爆发量和振幅的变化，而且这种变化可能影响胰岛素的作用。最后，搏动释放受损在早期2型糖尿病中的作用提示胰岛素搏动性研究在该疾病发展中的预测价值。糖尿病杂志（增刊1）：545 -5254,2002。
Insulin concentrations oscillate at a periodicity of 5-15 min per oscillation. These oscillations are due to coordinate insulin secretory bursts, from millions of islets. The generation of common secretory bursts requires strong within-islet and within-pancreas coordination to synchronize the secretory activity from the beta-cell pops ulation. The overall contribution of this pulsatile mechanism dominates and accounts for the majority of insulin release. This review discusses the methods involved in the detection and quantification of periodicities and individual secretory bursts. The mechanism by which overall insulin secretion is regulated through changes in the pulsatile component is discussed for nerves, metabolites, hormones, and drugs: The impaired pulsatile secretion of insulin in type 2 diabetes has resulted in much focus on the impact of the insulin delivery pattern on insulin action, and improved action from oscillatory insulin exposure is demonstrated on liver, muscle, and adipose tissues. Therefore, not only is the dominant regulation of insulin through changes in secretory burst mass and amplitude, but the changes may affect insulin action. Finally, the role of impaired pulsatile release in early type 2 diabetes suggests a predictive value of studies on insulin pulsatility in the development of this disease. Diabetes 51 (Suppl. 1): 5245-5254,2002.