Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm maze
Thalamic-cortical-striatal circuitry subserves working memory during delayed responding on a radial arm maze
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DOI：
10.1523/jneurosci.19-24-11061.1999
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发表时间：
1999-12-15
影响因子：
5.3
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Floresco, SB;Braaksma, DN;Phillips, AG
丘脑内侧背核（MDNt）、前额叶皮层和腹侧纹状体形成了一个相互连接的神经回路，可能有助于某些类型的工作记忆。本系列实验研究了大鼠在执行延迟和非延迟空间线索辐射臂迷宫任务时这些脑区之间的功能相互作用。在实验1中，短暂失活的MDNt的双侧注射利多卡因选择性地破坏延迟任务的性能，但不是在一个nondelayed随机觅食版本的径向臂迷宫任务。在实验2中，不对称的利多卡因注射到大脑一侧的MDNt和另一侧的前额叶皮层暂时断开这两个大脑区域，并显着损害觅食在延迟任务。同样地，前额叶皮层和前额叶核之间的断开也会破坏这项任务的觅食，而MDNt和前额叶核之间的断开则没有影响。这些数据表明，串行传输的信息之间的MDNt，前额叶皮层，和nucleus的试验时，唯一的，短期的空间记忆是用来指导前瞻性的搜索行为。结果进行了讨论，相对于一个分布式的神经网络连接边缘，丘脑，皮层和纹状体区域，介导的执行功能的工作记忆。
The medial dorsal nuclei of the thalamus (MDNt), the prefrontal cortex, and the ventral striatum form an interconnected neural circuit that may subserve certain types of working memory. The present series of experiments investigated functional interactions between these brain regions in rats during the performance of delayed and nondelayed spatially cued radial-arm maze tasks. In Experiment 1, transient inactivation of the MDNt by a bilateral injection of lidocaine selectively disrupted performance on a delayed task but not on a nondelayed random foraging version of the radial arm maze task. In Experiment 2, asymmetrical lidocaine injections into the MDNt on one side of the brain and the prefrontal cortex on the other transiently disconnected these two brain regions and significantly impaired foraging during the delayed task. Similarly, disconnections between the prefrontal cortex and the nucleus accumbens also disrupted foraging on this task, whereas disconnections between the MDNt and the nucleus accumbens had no effect. These data suggest that serial transmission of information among the MDNt, the prefrontal cortex, and the nucleus accumbens is required when trial-unique, short-term spatial memory is used to guide prospective search behavior. The results are discussed with respect to a distributed neural network linking limbic, thalamic, cortical, and striatal regions, which mediates executive functions of working memory.