Health related quality of life in a nationally representative sample of haematological patients
Health related quality of life in a nationally representative sample of haematological patients
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DOI：
10.1111/j.1600-0609.2009.01250.x
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发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
Groenvold, Mogens
中科院分区：
文献类型：
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作者：
Johnsen, Anna T.;Tholstrup, Dorte;Groenvold, Mogens
目的：血液病患者健康相关生活质量的知识是有限的。本研究的目的是调查的患病率和预测因子的症状和问题的血液病患者在丹麦的代表性样本。方法：随机抽样的白血病，多发性骨髓瘤和晚期淋巴瘤患者（n = 732）收到了欧洲组织的研究和治疗癌症的生活质量问卷（EORTC QLQ-C30）。计算平均评分。此外，使用两个阈值对评分进行二分：报告至少“一点点"EORTC QLQ-C30症状/问题的患者被归类为"症状/问题”，报告至少“相当多”的患者被归类为“严重症状/问题”。多元Logistic回归分析用于确定预测因子。结果：共470例（64%）患者参与。最常见的症状/问题是疲劳（55%;重度20%）、角色功能减退（49%;重度23%）、失眠（46%;重度15%）和疼痛（37%;重度15%）。年龄较大的患者和积极治疗的患者有更多的症状和问题。只有很少的证据表明，社会不平等。结论：这可能是第一个全国代表性的血液病患者的症状和问题的研究。这些患者有值得注意的症状/问题。健康相关的生活质量是血液系统恶性肿瘤的一个重要问题。
Objectives:Knowledge of health related quality of life of haematological patients is limited. This study aimed at investigating the prevalence and predictors of symptoms and problems in a representative sample of haematological patients in Denmark.Methods:A random sample of patients with leukaemia, multiple myeloma and advanced lymphoma (n = 732) received the European Organisation for Research and Treatment of Cancer quality-of-life questionnaire (EORTC QLQ-C30). Mean scores were calculated. In addition, scores were dichotomised using two thresholds: patients reporting at least 'a little' of each EORTC QLQ-C30 symptom/problem were classified as having a 'symptom/problem', and patients reporting at least 'quite a bit' were classified as having a 'severe symptom/problem'. Multiple logistic regression was used to identify predictors.Results:In total, 470 (64%) patients participated. The most frequent symptoms/problems were fatigue (55%; severe 20%), reduced role function (49%; severe 23%), insomnia (46%; severe 15%), and pain (37%; severe 15%). Older patients and patients in active antineoplastic treatment had more symptoms and problems. There was only little evidence of social inequalities.Conclusion:This is probably the first nationally representative study of symptoms and problems in haematological patients. These patients have symptoms/problems that deserve attention. Health related quality of life is an important issue in haematological malignancies.