The Effect of Risperidone on Cognition in Patients with Schizophrenia
The Effect of Risperidone on Cognition in Patients with Schizophrenia
复制标题
利培酮对精神分裂症患者认知的影响
DOI：
10.1177/070674379604100823
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
I. Lussier
中科院分区：
文献类型：
--
作者：
E. Stip;I. Lussier
目的：评价利培酮治疗6周和6个月后对认知功能的影响，并确定神经心理功能的改善是否与精神病理的改善有关。方法：在接受经典抗精神病药物治疗和辅助药物治疗的同时，对患者的精神和锥体外系症状进行评估。然后在改用利培酮的新治疗后对患者进行重新评估。结果：在利培酮治疗期间，精神分裂症患者主要在注意成分，特别是选择性注意和警觉性方面表现出改善。结论：在给予利培酮的患者中，精神病理的改善与外显记忆和警觉性认知测试的改善呈正相关。
Objective: To evaluate the effect of risperidone on cognitive functions after both 6 weeks and 6 months of treatment and to determine whether any improvement on neuropsychological function relates to improvement in psychopathology. Method: Patients' psychiatric and extrapyramidal symptoms were assessed while they were receiving classical neuroleptic treatment and adjunctive medications. Patients were then reassessed after changing to a new treatment of risperidone. Results: During treatment with risperidone, schizophrenic patients displayed improved performance mainly on attentional components, specifically, selective attention and alertness. Conclusion: In patients who were given risperidone, there was a positive correlation between improvement in psychopathology and improvement in cognitive tests of explicit memory and alertness.