Soluble Sema4D Level Is Positively Correlated with Sema4D Expression in PBMCs and Peripheral Blast Number in Acute Leukemia.
Soluble Sema4D Level Is Positively Correlated with Sema4D Expression in PBMCs and Peripheral Blast Number in Acute Leukemia.
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DOI：
10.1155/2022/1384471
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Xue L;Shi S;Lei H;Zhang Z;Tian X;Qiu L;Tang J;Kui L;Nan W;Cao X;Sun Q;Yu M;Jiang H
Semaphorin 4D（Sema 4D）在多种癌症和白血病中高度表达。它与急性白血病的发展有关。高水平的可溶性Sema 4D也存在于急性白血病患者的血浆中。然而，Sema 4D是否与急性白血病的临床特征相关仍不清楚。本研究检测了Sema 4D在急性白血病患者外周血单个核细胞（PBMC）和骨髓单个核细胞（BMMCs）中的表达，发现Sema 4D在B-急性淋巴细胞白血病（ALL）、T-ALL和急性髓细胞白血病（AML）患者的PBMC中以及B-ALL和AML患者的BMMCs中高度表达，而在T-ALL患者的BMMCs中不表达。Sema 4D在T-ALL患者PBMC中的表达高于B-ALL和AML患者。此外，化疗过程中B-ALL患者BMMCs中Sema 4D的表达降低。缓解组低于初治组和未缓解组。在急性白血病中，血清中可溶性Sema 4D水平与PBMC中Sema 4D表达、白细胞数和外周血原始细胞数呈正相关。这些结果表明，Sema 4D及其可溶性形式的水平与急性白血病的发展，并可能被视为一个潜在的生物标志物在儿童急性白血病。
Semaphorin 4D (Sema4D) is highly expressed in various cancers and leukemia. It is involved in the development of acute leukemia. A high level of soluble Sema4D is also present in the plasma of acute leukemia patients. However, it remains unknown whether Sema4D is associated with the clinical characteristics of acute leukemia. In this study, Sema4D expression was examined in peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with acute leukemia, and it was highly expressed in the PBMCs of B-acute lymphoblastic leukemia (ALL), T-ALL, and acute myeloid leukemia (AML) patients and in the BMMCs of B-ALL and AML patients but not in the BMMCs of T-ALL patients. Sema4D expression was higher in the PBMCs of T-ALL patients than in the PBMCs of B-ALL or AML patients. In addition, Sema4D expression in BMMCs was reduced in B-ALL patients during the chemotherapy process. It was lower in remission patients than in newly diagnosed and patients without remission. In acute leukemia, soluble Sema4D level in serum is positively correlated with Sema4D expression in PBMCs, leukocyte number, and peripheral blast number. Those results suggest that the levels of Sema4D and its soluble form are associated with acute leukemia development and may be regarded as a potential biomarker in pediatric acute leukemia.
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影响因子：
27.4
作者：
Nishide M;Nojima S;Ito D;Takamatsu H;Koyama S;Kang S;Kimura T;Morimoto K;Hosokawa T;Hayama Y;Kinehara Y;Kato Y;Nakatani T;Nakanishi Y;Tsuda T;Park JH;Hirano T;Shima Y;Narazaki M;Morii E;Kumanogoh A
通讯作者：
Kumanogoh A
影响因子：
8.3
作者：
Chen Y;Zhang L;Liu WX;Wang K
通讯作者：
Wang K
影响因子：
4
作者：
Jiang H;Chen C;Sun Q;Wu J;Qiu L;Gao C;Liu W;Yang J;Jun N;Dong J
通讯作者：
Dong J
影响因子：
7.3
作者：
Xie J;Wang Z;Wang W
通讯作者：
Wang W
影响因子：
3.8
作者：
Ikeya T;Maeda K;Nagahara H;Shibutani M;Iseki Y;Hirakawa K
通讯作者：
Hirakawa K