Lithium pharmacokinetics: single-dose experiments and analysis using a physiological model.
Lithium pharmacokinetics: single-dose experiments and analysis using a physiological model.
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锂药代动力学：使用生理模型的单剂量实验和分析。
DOI：
10.1007/bf01059545
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Diamond,JM
中科院分区：
文献类型：
--
作者：
Ehrlich,BE;Clausen,C;Diamond,JM
研究了健康人体单次给药后锂离子的分布动力学。同时观察血浆、红细胞（RBC）和尿液中Li+浓度的变化。数据通过一个简单但生理上真实的模型拟合，因此提取的速率常数可以分配到真实的身体隔室，并与细胞运输特性的独立测量结果进行比较。提取的速率常数用于计算红细胞和不可接近细胞（主要是肌肉）的稳态细胞与血浆Li+比率。在这两种类型的电池中，细胞内Li+浓度远低于电化学平衡。这一发现表明，红细胞的Li+反转运外排机制可能与肌肉相同。我们还提供了Li+排泄的昼夜节律与Na+和K+排泄的每日周期平行的证据。
The kinetics of lithium (Li+) distribution after a single dose was studied in healthy human subjects. Experiments were performed by simultaneously following changes of Li+concentration in plasma, erythrocytes (RBC), and urine. The data were fitted by a simple but physiologically realistic model, so that extracted rate constants could be assigned to real body compartments and compared with independent measurements of cellular transport characteristics. The extracted rate constants were used to calculate steady-state cell-to-plasma Li+ratios for RBC and for inaccessible cells (mainly muscle). In both cell types, the intracellular Li+concentration is far below electrochemical equilibrium. This finding suggests that the Li+countertransport efflux mechanism of RBC may be shared with muscle. We also present evidence for a circadian rhythm in Li+excretion that parallels the daily cycle of Na+and K+excretion.