Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal
Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal
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DOI：
10.1016/s0161-6420(95)30769-5
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发表时间：
1995-12-01
期刊：
影响因子：
13.7
通讯作者：
Foulks, GN
中科院分区：
文献类型：
--
作者：
Manning, FJ;Wehrly, SR;Foulks, GN
目的：通过比较主观感觉和客观染色评分，确定干眼患者和眼表正常患者对 1% 丽丝胺绿与 1% 孟加拉玫瑰花溶液的耐受性和眼表染色特征。方法：12 名干燥性角结膜炎患者和 8 名无眼表疾病的受试者按分级标准（0-5）记录他们的症状以及滴注一滴 1% 丽丝胺绿后症状的持续时间和1%孟加拉玫瑰在两个不同的场合以不同的顺序出现。其中一位作者以分级量表 (0-4) 记录了丽丝胺绿和孟加拉玫瑰染色模式。 结果：对于干燥性角结膜炎患者，丽丝胺绿的平均感觉评分 (2.42) 显着低于孟加拉玫瑰 (4.58) 的平均感觉评分 (P = 0.00006)。滴注孟加拉玫瑰花后，症状持续时间也显着延长（P = 0.0007）。对于没有眼表疾病的受试者，丽丝胺绿的平均感觉评分 (1.375) 显着低于孟加拉玫瑰 (2.5) (P = 0.01)。在该组中，滴注孟加拉玫瑰花后，症状持续时间也显着延长（P = 0.001）。两组的客观染色评分没有差异。结论：丽丝胺绿比孟加拉玫瑰色更能被患者耐受，并且在评估干燥性角结膜炎眼表方面与孟加拉玫瑰花同样有效。
Purpose: To determine patient tolerance and ocular surface staining characteristics of 1% lissamine green versus 1% rose bengal solutions in patients with dry eye and in those with normal ocular surfaces by comparison of subjective sensation and objective staining scores.Methods: Twelve patients with keratoconjunctivitis sicca and eight subjects with no ocular surface disease recorded their symptoms on a graded scale (0-5) and the duration of symptoms after instillation of one drop of 1% lissamine green and 1% rose bengal on two different occasions in different order. Lissamine green and rose bengal staining patterns were recorded on a graded scale (0-4) by one of the authors.Results: For patients with keratoconjunctivitis sicca mean sensation score with lissamine green (2.42) was significantly lower (P = 0.00006) than with rose bengal (4.58). The duration of symptoms was significantly longer (P = 0.0007) after rose bengal instillation as well. For subjects with no ocular surface disease, mean sensation score with lissamine green (1.375) was significantly lower (P = 0.01) than with rose bengal (2.5). In this group, duration of symptoms also was significantly longer (P = 0.001) after rose bengal instillation. In both groups, there was no difference in objective staining scores.Conclusion: Lissamine green is better tolerated than rose bengal by patients and is equally as effective as rose bengal in evaluating the ocular surface in keratoconjunctivitis sicca.