Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China.
Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China.
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我国不同民族溃疡性结肠炎患者肠道菌群差异
DOI：
10.1097/md.0000000000026932
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发表时间：
2021-08-13
期刊：
影响因子：
1.6
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Liu H;Liu W;Huang X;Feng Y;Lu J;Gao F
目的探讨维吾尔族和汉族溃疡性结肠炎(UC)患者肠道菌群的差异。采用高通量测序技术分析UC患者及其配对的健康配偶或一级亲属粪便细菌的微生物多样性和结构组成。维吾尔族UC患者(UUC)的粪便微生物多样性和丰度指数显著低于维吾尔族正常对照组(UUC)，而汉族UC患者(HUC)和汉族正常对照组(HN)之间差异无统计学意义。与各自的对照组相比，维吾尔族UC患者和汉族UC患者的肠道菌群组成不同(P <； .05)。UUC组的伯克霍尔德氏菌、卡巴拉氏菌、副伯克霍尔德氏菌的丰度高于HUC组，而HUC组的粪便杆菌、双歧杆菌和布鲁氏菌高于UUC组(P <； .05)。UUC组Veillonella高于维吾尔族正常对照组，而指甲下层和瘤胃球菌科Ucg-002显著低于维吾尔族正常对照组(P <； .05)。Huc组Prevotea_9显著高于HN组，Blautia、AnAerostipe和[Eubacum]_hallii_组显著低于HN组。重要度排名前6位的是克里斯滕森菌科R7群、瘤胃球菌UCG_005、瘤胃球菌_UCG_010、瘤胃球菌_UCG_013、嗜血杆菌和埃扎基氏菌。维吾尔族和汉族UC患者肠道菌群结构的差异可能是其临床异质性的原因之一。R7群、UCG_005、UCG_010、UCG_013、嗜血杆菌、Ezakiella可作为UC的预测标志物。
Abstract To determine the differences in intestinal flora between Uygur and Han patients with ulcerative colitis (UC). Microbial diversity and structural composition of fecal bacteria from patients with UC and their matched healthy spouses or first-degree relatives were analyzed using high-throughput sequencing technology. The fecal microbial diversity and abundance index of Uygur patients with UC (UUC) were significantly lower compared with the Uygur normal control group, while there was no significant difference between the Han UC patients (HUC) and the Han normal control group (HN). Compared with their respective control groups, Uygur UC patients and Han UC patients had a different main composition of human intestinal flora (P < .05). The abundance of Burkholderia, Caballeronia, Paraburkholderia in the UUC group were higher compared with the HUC group, while Faecalibacterium, Bifidobacterium, and Blautia in the HUC group were higher than those in the UUC group (P < .05). Veillonella in the UUC group was higher than that in the Uygur normal control group group, while Subdoligranulum and Ruminococcaceae_UCG-002 were significantly lower (P < .05). Prevotella_9 in the HUC group was significantly higher than that in HN group, while Blautia, Anaerostipes, and [Eubacterium]_hallii_group were significantly lower. Moreover, the top 6 species in order of importance were Christensenellaceae_R_7_group, Ruminococcae_ucg_005, Ruminococcae_ucg_010, Ruminococcae_ucg_013, Haemophilus, and Ezakiella. The difference in intestinal microflora structure may be one of the reasons for the clinical heterogeneity between Uygur and Han patients with UC. Christensenellaceae_R_7_group, Ruminococcae_ucg_005, Ruminococcae_ucg_010, Ruminococcae_ucg_013, Haemophilus, and Ezakiella could be used as potential biomarkers for predicting UC.