Decrease of Plasma Soluble (Pro)renin Receptor by Bariatric Surgery in Patients with Obstructive Sleep Apnea and Morbid Obesity
Decrease of Plasma Soluble (Pro)renin Receptor by Bariatric Surgery in Patients with Obstructive Sleep Apnea and Morbid Obesity
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DOI：
10.1089/met.2017.0153
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发表时间：
2018-03-20
影响因子：
2.1
通讯作者：
Sakurai, Shigeru
中科院分区：
文献类型：
--
作者：
Nishijima, Tsuguo;Ohba, Koji;Sakurai, Shigeru
背景：阻塞性睡眠呼吸暂停患者血浆中可溶性肾素受体[S(P)RR]浓度升高，但其在病态肥胖中的作用尚未见报道。本研究旨在阐明减重手术对阻塞性睡眠呼吸暂停综合征合并病态肥胖患者血浆S(P)RR浓度的影响，并找出其变化的相关因素。方法：对23例无慢性肾脏疾病的阻塞性睡眠呼吸暂停综合征合并病态肥胖患者(男10例，女13例；体重指数40.76.16 kg/m(2))患者进行减肥手术后的随访。分别于术前、术后4周、24周进行多导睡眠图(PSG)监测。PSG后每天清晨测定血浆S(P)RR浓度。结果：术前血浆S(P)RR浓度与血肌酐呈显著正相关(P
Background: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. Methods: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40.76.16kg/m(2)) without chronic kidney disease were followed up after bariatric surgery. Overnight polysomnography (PSG) was performed before surgery, and 4 and 24 weeks after surgery. Plasma s(P)RR concentrations were measured each morning after PSG. Results: Preoperative plasma s(P)RR concentrations showed significant positive correlations with serum creatinine (P